Advantage Multi Topical Solution for Cats, 9.1-18 lbs, (Purple Box), slide 1 of 1

Advantage Multi Topical Solution for Cats, 9.1-18 lbs, (Purple Box), 6 Doses (6-mos. supply)

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Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Advantage Multi for Cats is a broad-spectrum topical solution prescribed by veterinarians to provide pet parents with a convenient monthly application to help alleviate symptoms caused by pesky parasites. This easy-to-use solution works to kill adult fleas, treat and control ear mites, roundworm and hookworms—it may also help to prevent heartworm disease in some cats.


Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria Immitis in cats and ferrets 2 pounds or over. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. 

Possible Side Effects

Contact your veterinarian if your pet experiences pruritus/scratching, scabbing, redness, wounds and inflammation at the treatment site; lethargy; and chemical odor. 

Drug & Food Interactions

Talk to your veterinarian about any other drugs your dog is taking before starting this medication.


Do not dispense dose applicator tubes without complete safety and administration information. Avoid oral ingestion. Cats may experience hypersalivation, tremors, vomiting and decreased appetite if Advantage Multi for Cats is inadvertently administered orally or through grooming/licking of the application site. The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats. The effectiveness of Advantage Multi for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats. Use of this product in geriatric pets with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.

Dosage Chart

Color on BoxWeight RangeVolumeStrengthDosageProduct Page
Orange5.1 lbs-9lbs & Ferrets0.4 mL40 mg Imidacloprid & 4 mg MoxidectinApply each dose once a month✓-Click Here
Purple9.1 lbs-18 lbs0.8 mL80 mg Imidacloprid & 8 mg Moxidectin Apply each dose once a month✓-Click Here
  1. Prescribing Information

See all items by Advantage Multi

  • Item Number
  • Common Brand Name(s)
    Advantage Multi
  • Generic Name
    Imidacloprid, Moxidectin
  • For Use With
  • Administration Form
  • Brand
  • Breed Size
    Medium Breeds
  • Product Form
  • Strength
    80 mg Imidacloprid and 8 mg Moxidectin
  • Health Condition
    Heartworms, Fleas, Roundworms, Hookworms, Ear Mites
  • Drug Type

Active ingredients: 80 mg Imidacloprid (10%), 8 mg Moxidectin (1%)

Recommended Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Storage Instructions

Store at room temperature between 39° - 77°F.


How often can I use Advantage Multi for Cats?

Use monthly (every 30 days), year-round, to kill fleas; treat flea infestations; treat and control ear mites, hookworms and roundworms; and prevent heartworm disease.

When should I put Advantage Multi for Cats on my cat?

You should apply Advantage Multi for Cats monthly (every 30 days), all year-round.

How do I apply Advantage Multi for Cats?

Do not apply to irritated skin.

  • Remove one dose applicator tube from the package.
  • While holding the tube in an upright position, remove the cap from the tube.
  • Turn the cap over and push the other end of the cap onto the tip of the tube.
  • Twist the cap to break the seal and then remove cap from the tube.
  • Part the hair on the back of the cat's neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift the tube away from skin before releasing pressure on the tube.

Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming.

How old does my cat have to be to use Advantage Multi for Cats?

Advantage Multi for Cats can be used on cats at least 9 weeks old, weighing at least 2 pounds. The small cat size (5.1-9 lbs.) can be used for ferrets that weigh at least 2 pounds.

Does Advantage Multi for Cats expire?

Advantage Multi for Cats does have an expiration date that can be found on the bottom edge of the package. Advantage Multi for Cats should not be used past its expiration date.

Does Advantage Multi for Cats kill ticks?

No. Advantage Multi for Cats helps provide broad-spectrum protection against fleas, ear mites, roundworms, hookworms and heartworms. If you are concerned about ticks, Bayer has effective products that treat and prevent tick infestations.

How does Advantage Multi for Cats work to kill fleas?

Advantage Multi for Cats is applied to the pet's skin. The active ingredient spreads over your cat's body to kill fleas through contact so they do not have to bite your cat to die.

What if I miss an Advantage Multi for Cats heartworm treatment?

Life happens. If you forget or miss a dose, simply treat your cat immediately. Advantage Multi for Cats is heartworm prevention that forgives if you forget. It kills newly acquired heartworm larvae (baby worms) throughout the month to prevent further infection. After a single dose, if you forget and go more than 30 days in between treatments, just treat immediately and resume your monthly schedule.

Rating: 4.8 of 5 stars 65 Reviews 65 Reviews 4.8 out of 5 Stars

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97% Recommend

97% of reviewersrecommend this product

Rating: 4.8 of 5 stars 4.8 / 5

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65 Reviews

Showing 1-10 of 65 Reviews

  • 5 out of 5 stars

    Demodex Gatoi Mites

    By lbkinflorida on Feb 12, 2021 Top 250 Contributor

    Our cat tested positive for Demodex Mites by a very skilled veterinary dermatologist who did skin scrapings. We had to apply this product every two weeks for two months. After the first month, she was rechecked and came back mite-free. Our poor kitty had a horrible infestation. Chemo treatments for large cell lymphoma destroyed her immune system. The prednisolone she was on further dampened her immunity and the mites took over. She looked and felt horrible. It was heartbreaking. This product and a great dermatologist saved her life.

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  • 5 out of 5 stars


    By None on Feb 25, 2021

    I was so pleased with how easy it was to get my first order. It came in a timely manor, also. Yet, I am having a very hard time getting my 2nd order. I'm not very computer literate and I'm trying to get on auto-ship. I've sent a message yet I've not heard back. But, I do want to make it clear I am very pleased with the product.

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  • 5 out of 5 stars


    By Samantha on Jan 26, 2021

    This works!! Use exactly as directed, and within hours you will literally see the dead fleas falling off of your cat. I'm always skeptical of topical treatments, I would prefer oral. But this might have changed my mind forever! I would recommend combing your little one a few hours after application has dried and is working, just to get rid of the rest of the dead fleas.

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  • 5 out of 5 stars

    More than flea protection

    By HumaneShopper on Feb 1, 2021

    Advantage Multi kills ear mites, as well as fleas and many other parasites. It really does remain active for at least a month. I wouldn't use anything else on my fur kids. And none of them has ever had an adverse reaction.

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  • 5 out of 5 stars

    Easy to use

    By wpooh617 on Jan 22, 2021

    Our once outdoor cat isn't always easy to administer care to, but the ease of this product helped us to help him. It does stay wet for a couple days but no problem. He didn't even act like anything was applied to his skin.

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  • 5 out of 5 stars

    Cat Hates It

    By Jezahlie on Sep 10, 2020

    -1/10 from my cat, he says it's garbage and squints at me when it's on him. 10/10 from me, because I hate bugs and itchy cats. 8/10 for clinic response time. It's an outside company asking permission from a clinic who sells it themselves. I can see why they wouldn't want to, so I appreciate that they even approved it. I had to reach out to Chewy for someone to contact my vet 4 days after the order was placed because there was no response from the clinic. 3/10 FedEx. They just don't... *sigh*.

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  • 5 out of 5 stars

    My account

    By Katlady on Oct 7, 2020

    Thank you for contacting my veterinarian for approval and speedy delivery on this order I’m very happy with all my purchases and speedy deliveries. I’m all stocked up now, but will be reordering pcbgalsoon. Thanks again

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  • 5 out of 5 stars

    AWESOME Customer Service!!

    By TOliver on Aug 29, 2020

    I have been buying all of my cat litter, food and flea prevention for four kitties from Chewy for years! Love all of their products, huge selection of products and you get your order so fast!!! Thanks Chewy for knowing how to treat your customers!!

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  • 5 out of 5 stars

    Good price

    By Lynn on Dec 12, 2020

    Good price and you just cannot beat their delivery fast!

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  • 1 out of 5 stars

    Has stopped working for my cats.

    By Review on Oct 28, 2020

    This product used to work very well, but it has stopped working the last couple of times.

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