10 Best Digestive Supplements & Probiotics for Horses 2025: According to Reviews | Chewy

The 10 Best Digestive Supplements & Probiotics for Horses

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How we created this digestive supplements & probiotic list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best digestive supplements & probiotics for horse.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best digestive supplements & probiotics for horses.

Key digestive supplements & probiotic considerations

Digestive Enzymes

Prebiotics

Probiotic Strains

Quality Ingredients

1
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count
Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count

Probios Equine Probiotic Apple Flavor Soft Chew Horse Supplement, 60 count

Rated 4.8 out of 5 stars
544
$16.97Chewy Price
($0.29/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.7/5
Excellent

Prebiotics

4.6/5
Excellent

Probiotic Strains

4.7/5
Excellent

Quality Ingredients

4.6/5
Excellent

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Oat Flour, Cane Molasses, Barley Flour, Brewers Dried Yeast, Glycerin

Food Flavor

Apple, Fruits & Vegetables

Farm Animal Type

Horse
2
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe
Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe

Ulcergard Omeprazole Paste Horse Treatment, 1 syringe, .22-oz syringe

Rated 4.9 out of 5 stars
244
$42.99Chewy Price
($195.41/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.5/5
Great

Prebiotics

4.7/5
Excellent

Probiotic Strains

4.5/5
Great

Quality Ingredients

4.5/5
Great

Is this digestive supplements & probiotic right for my pet?

Lifestage

Adult, All Lifestages

Top Ingredient

Active Ingredient: Omeprazole

Farm Animal Type

Horse

Health Feature

Digestive Health
3
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket
Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket

Farnam SandClear Natural Psyllium Fiber Crumbles Apple/Molasses Flavor Horse Supplement, 10-lb bucket

Rated 4.8 out of 5 stars
331
$79.99Chewy Price
($2.50/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.6/5
Excellent

Prebiotics

4.5/5
Great

Probiotic Strains

4.4/5
Great

Quality Ingredients

4.4/5
Great

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Psyllium Seed Husk, Wheat Middlings, Natural And Artificial Flavors, Alfalfa Meal, Dehydrated

Food Flavor

Apple, Molasses, Fruits & Vegetables, Herbs & Spices

Farm Animal Type

Horse
4
AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub
AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub
AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub
AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub
AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub

AniMed Professional Strength Remission Hoof Health Powder Horse Supplement, 4-lb tub

Rated 4.7 out of 5 stars
307
$35.49Chewy Price
($0.28/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.3/5
Great

Prebiotics

4.3/5
Great

Probiotic Strains

4.4/5
Great

Quality Ingredients

4.4/5
Great

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Magnesium Oxide, Flaxseed Meal, Stabilized Rice Bran, Brewer's Yeast, Chromium Tripicolinate

Farm Animal Type

Horse

Food Form

Supplement
5
Finish Line U-7 Gastric Aid Liquid Horse Supplement, 128-fl oz bottle
Finish Line U-7 Gastric Aid Liquid Horse Supplement, 128-fl oz bottle
Finish Line U-7 Gastric Aid Liquid Horse Supplement, 128-fl oz bottle
Finish Line U-7 Gastric Aid Liquid Horse Supplement, 128-fl oz bottle

Finish Line U-7 Gastric Aid Liquid Horse Supplement, 128-fl oz bottle

Rated 4.9 out of 5 stars
85
$77.73Chewy Price
($0.61/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.8/5
Excellent

Prebiotics

4.7/5
Excellent

Probiotic Strains

4.5/5
Great

Quality Ingredients

4.7/5
Excellent

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Ascorbic Acid, MSM, Apple Pectin, Brewer's Yeast, Grape Seed Extract

Special Diet

Flax-Free, No Corn No Wheat No Soy

Farm Animal Type

Horse
6
Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block
Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block
Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block
Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block
Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block

Tribute Equine Nutrition Constant Comfort Gastric Health Horse Supplement, 15-lbs block

Rated 4.6 out of 5 stars
215
$17.99Chewy Price
($0.90/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.2/5
Great

Prebiotics

4.4/5
Great

Probiotic Strains

4.3/5
Great

Quality Ingredients

4.4/5
Great

Is this digestive supplements & probiotic right for my pet?

Top Ingredients

Dehydrated Alfalfa Meal, Salt, Wheat Middlings, Seaweed Derived Calcium, Cane Molasses

Farm Animal Type

Horse

Food Form

Feeders / Blocks, Supplement

Health Feature

Digestive Health
7
Equa Holistics HealthyGut Maintenance Probiotics Powder Horse Supplement, 25.5-oz tub
Equa Holistics HealthyGut Maintenance Probiotics Powder Horse Supplement, 25.5-oz tub
Equa Holistics HealthyGut Maintenance Probiotics Powder Horse Supplement, 25.5-oz tub
Equa Holistics HealthyGut Maintenance Probiotics Powder Horse Supplement, 25.5-oz tub

Equa Holistics HealthyGut Maintenance Probiotics Powder Horse Supplement, 25.5-oz tub

Rated 4.7 out of 5 stars
55
$69.95Chewy Price
($0.78/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.6/5
Excellent

Prebiotics

4.5/5
Great

Probiotic Strains

4.6/5
Excellent

Quality Ingredients

4.8/5
Excellent

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Inulin, Rice Extract, Active Dry Yeast, Dried Propionibacterium Freudenreichii Fermentation Product, Dried Propionibacterium Shermanii Fermentation Product

Special Diet

No Corn No Wheat No Soy, Human-Grade, Sugar Free, Natural...

Farm Animal Type

Horse
8
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag
Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag

Manna Pro Opti-Zyme Microbial Probiotic Digestive Hindgut Health Granules Horse, Cattle, Pigs, Sheep & Goat Supplement, 3-lb bag

Rated 4.8 out of 5 stars
39
$19.99Chewy Price
($0.42/serving)
Promo, Save 40% on first Autoship with code EQSUP

Our ratings

Digestive Enzymes

4.5/5
Great

Prebiotics

4.6/5
Excellent

Probiotic Strains

4.6/5
Excellent

Quality Ingredients

4.4/5
Great

Is this digestive supplements & probiotic right for my pet?

Top Ingredients

Yeast Culture, Active Dry Yeast (Saccharomyces Cerevisiae), Cobalt Glucoheptonate, Dried Aspergillus Oryzae Fermentation Solubles, Dried Bacillus Licheniformis Fermentation Solubles

Farm Animal Type

Horse

Food Form

Supplement, Granulated

Health Feature

Digestive Health
9
Kentucky Equine Research EquiShure Time-Released Hindgut Buffer Powder Horse Supplement, 2.75-lb bag
Kentucky Equine Research EquiShure Time-Released Hindgut Buffer Powder Horse Supplement, 2.75-lb bag
Kentucky Equine Research EquiShure Time-Released Hindgut Buffer Powder Horse Supplement, 2.75-lb bag
Kentucky Equine Research EquiShure Time-Released Hindgut Buffer Powder Horse Supplement, 2.75-lb bag

Kentucky Equine Research EquiShure Time-Released Hindgut Buffer Powder Horse Supplement, 2.75-lb bag

Rated 4.8 out of 5 stars
51
$49.99Chewy Price
($2.39/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.4/5
Great

Prebiotics

4.2/5
Great

Probiotic Strains

4.2/5
Great

Quality Ingredients

4.3/5
Great

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Monoglycerides, sodium bicarbonate, hydrogenated vegetable oil., Active Ingredients: Sodium bicarbonate

Special Diet

Molasses-Free, Low Glycemic, Low NSC, Low Starch...

Food Flavor

Unflavored
10
Grand Meadows Grand Complete Comprehensive Support Powder Horse Supplement, 5-lb tub
Grand Meadows Grand Complete Comprehensive Support Powder Horse Supplement, 5-lb tub
Grand Meadows Grand Complete Comprehensive Support Powder Horse Supplement, 5-lb tub
Grand Meadows Grand Complete Comprehensive Support Powder Horse Supplement, 5-lb tub

Grand Meadows Grand Complete Comprehensive Support Powder Horse Supplement, 5-lb tub

Rated 4.9 out of 5 stars
30
$53.05Chewy Price
($1.33/serving)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Digestive Enzymes

4.7/5
Excellent

Prebiotics

4.6/5
Excellent

Probiotic Strains

4.6/5
Excellent

Quality Ingredients

4.7/5
Excellent

Is this digestive supplements & probiotic right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Glucosamine HCL, MSM, Manganese, Methionine, Lysine

Special Diet

Plant Based, Grain-Free

Food Flavor

Flax, Herbs & Spices