10 Best Large Breed Puppy Health & Wellness Products 2025: According to Reviews | Chewy

The 10 Best Large Breed Puppy Health & Wellness Products

Top-Rated Customer Favorites

Looking for the best health and wellness products for large-breed puppies? These are the top-rated products that Chewy pet parents with large-breed puppies, like you, love. Products are ranked by number of purchases, number of reviews, and star ratings.

1
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram
Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram

Virbac C.E.T. Enzymatic Poultry Flavor Dog & Cat Toothpaste, 70 gram

Rated 4.7 out of 5 stars
4,916
$11.89Chewy Price
($0.17/g)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Glucose Oxidase, Lactoperoxidase, Sorbitol, Purified Water, Dicalcium Phosphate Anhydrous

Food Flavor

Chicken
2
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count
Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count

Nutramax Dasuquin Hip & Joint Soft Chews Joint Supplement for Large Dogs, 150 count

Rated 4.7 out of 5 stars
7,131
$83.99Chewy Price
($0.56/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables, MSM (Methylsulfonylmethane), Boswellia Serrate Extract

Health Feature

Hip & Joint Support
3
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle
Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle

Native Pet Omega-3 Fish Oil & Alaskan Salmon Oil Skin & Coat Health Supplement for Dogs, 8-fl oz bottle

Rated 4.5 out of 5 stars
1,993
$16.99Chewy Price
($2.13/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Wild-caught pollock oil, wheat germ oil, wild-caught salmon oil, biotin, mixed tocopherol (natural preservative)

Special Diet

Limited Ingredient Diet, Human-Grade, Natural
4
PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle
PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle
PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle
PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle
PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle

PetAg Dyne High Calorie Liquid Nutritional Supplement for Dogs & Puppies 8 Weeks & Older, 16-fl oz bottle

Rated 4.4 out of 5 stars
618
$17.72Chewy Price
($1.11/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Soybean Oil, Sugar, Water, Glycerin, Dried Skimmed Milk

Special Diet

High Fat
5
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue
Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue

Jasper 360 Dog Finger Toothbrush & Storage Case, 2 count, Blue

Rated 4.5 out of 5 stars
1,449
$13.99Chewy Price
($7.00/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Health Feature

Dental & Breath Care
6
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit
Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit

Nylabone Advanced Oral Care Original Flavor Puppy Dental Kit

Rated 4.4 out of 5 stars
195
$11.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Sorbitol, Water, Silica, Glycerin, Cellulose Gum

Food Flavor

Original
7
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar
Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar

Miracle Care Kwik-Stop Styptic Powder for Dogs, Cats & Birds, .5-oz jar

Rated 4.7 out of 5 stars
994
$9.90Chewy Price
($19.80/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Ferric Subsulfate, Aluminum Chloride, Diatomite, Bentonite, Copper Sulfate

Health Feature

First Aid
8
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz
Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz

Sentry Petrodex Veterinary Strength Enzymatic Poultry Flavor Dog Toothpaste, 6.2-oz

Rated 4.7 out of 5 stars
1,906
$9.99Chewy Price
($1.62/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Sorbitol, hydrated silica, glycerin, water, poultry digest

Food Flavor

Chicken
9
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count
Nylabone Advanced Oral Care Finger Dog Brush, 2 count

Nylabone Advanced Oral Care Finger Dog Brush, 2 count

Rated 4.3 out of 5 stars
598
$5.67Chewy Price
($2.84/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Health Feature

Dental & Breath Care
10
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle
Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle

Vet's Best Enzymatic Dog Toothpaste, 3.5-oz bottle

Rated 4.6 out of 5 stars
1,256
$9.53Chewy Price
($2.73/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this large breed puppy health & wellness product right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Glycerin, Aloe, Pectin, Neem Oil, Grapefruit Seed Extract

Food Flavor

Unflavored

Frequently Asked Questions about Large Breed Puppy Health & Wellness Products

What health and wellness supplies will I need for a large-breed puppy?

You will likely need a few essential monthly health and wellness supplies for a large-breed puppy. Many experts recommend starting your puppy on the path to good oral health by getting him used to regular toothbrushing. Special dog toothbrushes and dog toothpastes can help make the process smoother and easier for both of you. Your puppy may also benefit from specific supplements like joint health supplements, omega supplements, or probiotics for digestive support. Ask your vet which health and wellness supplies might be best for your large-breed puppy.

Do I need dental supplies for a large-breed puppy?

You do need a few dental supplies for a large-breed puppy. In addition to lots of healthy things to chew, dental supplies like a dog toothbrush, dog toothpaste, and/or a dental water additive can help keep your puppy's teeth clean and strong as he grows. Talk to your vet about a good oral hygiene regimen for your large-breed puppy and ask about which oral care kits and products might be best.

Should I get health and wellness supplements for my large-breed puppy?

You should only get health and wellness supplements for your large-breed puppy if your vet recommends them. Your vet has the expertise to assess your puppy's health and determine whether certain supplements may be a good choice, as some supplements may be inappropriate or even hazardous for puppies. However, there are many dog health and wellness supplements that can be safe and helpful for puppies. Commonly recommended supplements for large-breed puppies include allergy, calming, skin and coat, vitamin, probiotic, and digestive supplements.