Douxo S3 PYO Antiseptic Antifungal Chlorhexidine Dog & Cat Wipes 30 count

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About This Item

Details

  • Soothe irritated skin on dogs and cats with this convenient wipe.
  • Formulated with ophytrium, a natural ingredient that helps strengthen the skin’s physical barrier.
  • Helps restore the balance of protective microbes.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

Ingredients

Instructions

Dermatological Treatment for Skin Issues

Developed with veterinary dermatologists, Douxo S3 offers expert solutions for pets with skin issues. The range includes shampoos, mousses, and pads—designed for daily use and to meet specific skin needs.

Made to Manage Common Skin Conditions

Douxo S3 is made to help manage common skin conditions like allergies, yeast or bacterial overgrowth, and seborrhea. Free from sulfates, parabens, colorants, and silicones, it’s pH-adjusted, soap-free, and hypoallergenic.

Featuring High-Performing Ingredients

 All Douxo S3 formulas contain Ophytrium, a natural-origin, triple-action ingredient that soothes, rebalances and strengthens the skin barrier. Other high-quality ingredients are selected to provide specific benefits in each formula. 

Easy Care for Pleasant Moments

Douxo S3 is designed to make every routine more pleasant for pets and people, with delightful textures and scents and ergonomic packaging. Co-developed with pet parents, it offers a complete skincare solution that’s easy and enjoyable to use.

About Douxo

Backed by 20+ years of expertise in veterinary dermatology, Douxo is designed to make grooming a better experience for both you and your pets.            

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Questions & Answers

25 Customer Questions

Is this safe to use around a dog’s mouth?

Answer by Chewy • Jul 28, 2021
These wipes are for external use only. It is safe to use on Ear Crusts, Facial Folds, Foot Pads (Do not use between the toes of cats), Hot Spots, Saliva Stains, Skin Folds, Tear Stains, and Chin Acne. It should not make contact with your pets eyes.

Can I use them for cleaning the dog's ears?

Answer by Chewy • Aug 19, 2021
These wipes are for external use only. It is safe to use on Ear Crusts, Facial Folds, Foot Pads (Do not use between the toes of cats), Hot Spots, Saliva Stains, Skin Folds, Tear Stains, and Chin Acne. It should not make contact with your pets eyes.

can i use these pad in between toes on dogs?

Answer by Chewy • Feb 20, 2023
These wipes can be used on a dog's foot however, they should not be used between the toes of cats.

Do you let area air dry after using pads

Answer by Chewy • Mar 08, 2022
We do recommend letting the area the Douxo S3 PYO Antiseptic Antifungal Chlorhexidine wipes were applied to get some time to air dry.
Reviews
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4.7
Rated 4.7 out of 5 stars
2060 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

89% Positive

Ease of Use

93% Positive

Effectiveness

92% Positive

Safety

91% Positive

572 Customer Reviews

Rated 5 out of 5 stars
By Fernanda on Dec 19, 2025

Great medicated wipes

We needed to use the wipes on Winnie’s ears due to a secondary infection. It helped us maintain the area properly cleaned and disinfected in between moisturizing

We needed to use the wipes on Winnie’s ears due to a secondary infection. It helped us maintain the area properly cleaned and disinfected in between moisturizing agents. I know it sounds weird but that is what the derm indicated. We are 3 weeks in the treatment plan and his ears have improved a lot. We’ve have also used it in hot spots before and they definitely helped. The medicated shampoo and cleaning with the wipes or the mousse in between baths works wonders!

Rated 5 out of 5 stars
By Chuck on Jan 16, 2026

It works!!

My cat will scratch right above his eye non stop and make it bleed, plus his ears. I put a cone on him until I found this stuff. It worked over night and he hasn’t

My cat will scratch right above his eye non stop and make it bleed, plus his ears. I put a cone on him until I found this stuff. It worked over night and he hasn’t scratched at all!! This stuff is amazing!

Rated 2 out of 5 stars
By Cressida on Jan 17, 2026

Go with the foam.

These feel semi dry in the container and I feel like I have to use at least three to four just to saturate the area. Again, good product. Recommended by my pups

These feel semi dry in the container and I feel like I have to use at least three to four just to saturate the area. Again, good product. Recommended by my pups vet but again, go with the foam.

Rated 5 out of 5 stars
By Alison on Oct 14, 2025
Top 250 Contributor

My Vet recommends this for so many issues !

I’ve used this on hot spots ( the foam is best imho bc it’s easy to apply thru fur ) I rarely buy the pads because they’re not a very good value, but they’re good

I’ve used this on hot spots ( the foam is best imho bc it’s easy to apply thru fur ) I rarely buy the pads because they’re not a very good value, but they’re good item. I use them for my dog’s feet she has itchy feet thatshe was chewing on, so I go in between her toes and clean each foot with these pads and then I top her off with “tiger toes” grip socks . . I think they sell these on chewy too. They’re they’re the little socks that have grip socks and they’re breathable so that keeps her from chewing in her feet. I use this every time if you’ve got itchy feet you clean them with this (if it’s coming from allergies ) and then tiger toes. I think chewy sells “tiger toes” too! They’re by far the best thing I found in the last five years for my dogs because they’re breathable so you can use them for so many different reasons.( like trying to keep them from chewing on feet ) & you can use them if you’ve got an elderly dog for them to get up easier - relatively inexpensive too

Rated 5 out of 5 stars
By Tara on Jan 19, 2026

Better quality

I use these for my dogs paws during allergy season. I have tried cheaper brands and the quality is just not the same. I will be sticking with this brand.

I use these for my dogs paws during allergy season. I have tried cheaper brands and the quality is just not the same. I will be sticking with this brand.

Rated 2 out of 5 stars
By Melissa on Nov 21, 2025

Ok for some cats not all

Bought this because I saw online it was good for cat acne. I didnt notice any negative affects with one of my cat's, but my younger cat broke out with even worse

Bought this because I saw online it was good for cat acne. I didnt notice any negative affects with one of my cat's, but my younger cat broke out with even worse acne and a rash that looked like carpet burn. Not sure if she had an allergic reaction, but I wont be using this on either of my cats cat.

Rated 5 out of 5 stars
By Robin on Oct 28, 2025

It’s helping. Pleasant low odor

My bulldog has troubles in his folds. This is not completely getting rid of it but that’s because of other issues. However it’s working better than anything we’ve

My bulldog has troubles in his folds. This is not completely getting rid of it but that’s because of other issues. However it’s working better than anything we’ve tried so far. It’s not as strong smelling so he doesn’t fight me so much. Dermatologist recommended this one. She didn’t expect it to be perfect either, he’s got more than one issue. I like better than the other non prescription wipes.

Rated 5 out of 5 stars
By D on Dec 31, 2025

Works well

My dog had lip fold pyoderma and his dermatologist recommended this in conjunction with a topical antibiotic and for long term maintenance! Works great!

My dog had lip fold pyoderma and his dermatologist recommended this in conjunction with a topical antibiotic and for long term maintenance! Works great!

Rated 5 out of 5 stars
By Wanda on Sep 21, 2025

Great at removing paw pad fungus

Louie was recently diagnosed with diabetes and so things he usually could take care of himself were now causing severe issues. Case in point, he had a fungal infection

Louie was recently diagnosed with diabetes and so things he usually could take care of himself were now causing severe issues. Case in point, he had a fungal infection in a front paw that caused his skin to disintegrate AND he was bit by an insect in the same paw but on top. His vet had me clean the paw with this product 3x/day and rubbing Animox into the areas. Cleared up in approx 2 weeks. Granted, he also had to wear a cone but the outcome was a healed paw. This dog momma now keeps this stuff readily available since we are still trying to get his diabetes under control.

Rated 5 out of 5 stars
By Robert on Jan 18, 2026

Good price

It seems to be working to prevent ear infections. Those long floppy ears seem to be prone to infection.

It seems to be working to prevent ear infections. Those long floppy ears seem to be prone to infection.