Douxo S3 PYO Antiseptic Antifungal Chlorhexidine Dog & Cat Shampoo, 16.9-oz bottle

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At a Glance

  • Skin & Coat Health
  • All Lifestages
  • All Breeds

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About This Item

Details

  • Shampoo soothes, cleans and strengthens irritated skin for dogs and cats.
  • Formulated with ophytrium, a natural ingredient that helps strengthen the skin’s physical barrier.
  • Helps restore the balance of protective microbes.
  • Made without soaps or sulfates.
  • Free of parabens, dyes and nanoparticles.

Ingredients

Instructions

Dermatological Treatment for Skin Issues

Developed with veterinary dermatologists, Douxo S3 offers expert solutions for pets with skin issues. The range includes shampoos, mousses, and pads—designed for daily use and to meet specific skin needs.

Made to Manage Common Skin Conditions

Douxo S3 is made to help manage common skin conditions like allergies, yeast or bacterial overgrowth, and seborrhea. Free from sulfates, parabens, colorants, and silicones, it’s pH-adjusted, soap-free, and hypoallergenic.

Featuring High-Performing Ingredients

 All Douxo S3 formulas contain Ophytrium, a natural-origin, triple-action ingredient that soothes, rebalances and strengthens the skin barrier. Other high-quality ingredients are selected to provide specific benefits in each formula. 

Easy Care for Pleasant Moments

Douxo S3 is designed to make every routine more pleasant for pets and people, with delightful textures and scents and ergonomic packaging. Co-developed with pet parents, it offers a complete skincare solution that’s easy and enjoyable to use.

About Douxo

Backed by 20+ years of expertise in veterinary dermatology, Douxo is designed to make grooming a better experience for both you and your pets.            

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Questions & Answers

19 Customer Questions

What is the difference between this formula and the PS formula?

Answer by Chewy • Aug 25, 2021
The Douxo S3 Pyo has replaced the Douxo Chlorhexidine products. One of the main ingredients in the Douxo line, Phytospingosine, has been replaced by a combination of ingredients called Ophytrium. Ophytrium helps supports the skin's physical barrier, helps support the microbial flora of healthy skin, and helps sooth red, itchy, and irritated skin.

What are the inactive ingredients

Answer by Chewy • Aug 16, 2022
The inactive ingredients in this shampoo are water, Cocamidopropyl hydroxysultaine, decyl glucoside, capryloyl glycine, pentavitin (saccharide isomerate), panthenol, coco + vanilla hypoallergenic fragrance, PEG-200 glyceryl stearate, phenoxyethanol, citric acid, and sodium hydroxide.

Can I use doucos3 SHAMPOO on my kitten (18 weeks old)and has tested positive for ringworm but no lesions (lesions gone but still positive)

Answer by Chewy • Sep 15, 2021
There is no age requirement for this shampoo, it is suitable for cats and dogs of all ages. Please reach out to your veterinarian as they know your pet and what is the best for your situation.

How frequently should this be used?

Answer by Chewy • Jul 08, 2025
It is recommended to bathe with the shampoo once, then apply the mousse by this brand, two times the first week (roughly every other day), then apply the mousse three times weekly for two weeks. It is recommended to reevaluate the skin with a veterinarian following this three-week treatment.
Reviews
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4.7
Rated 4.7 out of 5 stars
1802 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

85% Positive

Ease of Use

91% Positive

Effectiveness

94% Positive

Safety

87% Positive

520 Customer Reviews

Rated 2 out of 5 stars
By Bulldog mom on Jan 10, 2026

Streaky

I just finished washing my boyz in this soap and it had white streaks in it. I kept shaking it ti mix it better. I've gotten this soap from other places and its

I just finished washing my boyz in this soap and it had white streaks in it. I kept shaking it ti mix it better. I've gotten this soap from other places and its usually a light clear tan color with no white streaks. Other than that I haven't had any issues.

Rated 5 out of 5 stars
By Aileen on Jan 18, 2026

Very Effective Shampoo

The vet recommended this since my dog gets yeast infections and itchy skin. It is very effective. I do have to shampoo more frequently when he is having an issue,

The vet recommended this since my dog gets yeast infections and itchy skin. It is very effective. I do have to shampoo more frequently when he is having an issue, but I leave it on the skin for 10 minutes and it works great.

Rated 5 out of 5 stars
By Leilani on Dec 7, 2025

Lathery

A pump goes a long way although recommended doses are on back of bottle. It is very lathery and foamy which is easier to massage the skin. Leave for minutes and

A pump goes a long way although recommended doses are on back of bottle. It is very lathery and foamy which is easier to massage the skin. Leave for minutes and rinse. Helps my dog stop the itch. She actually enjoyed the bath and me bathing her. So it is soothing not sting feeling if that makes sense. Her skin already looks better. Recommended by her vet for food allergy.

Rated 5 out of 5 stars
By Linda on Jan 25, 2026

Stops Scratching

My guy is mostly Chow Chow and when young, was always scratching. He got regular flea and tick medication but still scratched. The vet recommended this and the

My guy is mostly Chow Chow and when young, was always scratching. He got regular flea and tick medication but still scratched. The vet recommended this and the scratching stopped.

Rated 5 out of 5 stars
By Susan on Dec 27, 2025

Soothing shampoo

This is a great product to help manage my dog's allergies. It's mild and soothing to his itchy skin and helps soften and loosen the scaly patches so I can gently

This is a great product to help manage my dog's allergies. It's mild and soothing to his itchy skin and helps soften and loosen the scaly patches so I can gently wash them away. It also helps prevent skin infection in areas he's scratched or licked.

Rated 5 out of 5 stars
By Glennita on Dec 30, 2025

This product plus its companion mousse worked!!!

A dog dermatologist prescribed this plus its companion mousse for my shih tzu who had very bad skin lesion for a year and these products (plus some oral med) clear

A dog dermatologist prescribed this plus its companion mousse for my shih tzu who had very bad skin lesion for a year and these products (plus some oral med) clear her skin up. I continue to use it all the time to keep her skin clear.

Rated 5 out of 5 stars
By Susan on Dec 28, 2025

Made her not stinky anymore

My dog Quinn had a yeasty smell, I tried the same shampoo but the calming that we had. It didn’t help with her smell so I ordered this some and it took it away with

My dog Quinn had a yeasty smell, I tried the same shampoo but the calming that we had. It didn’t help with her smell so I ordered this some and it took it away with the first wash. So pleased

Rated 4 out of 5 stars
By Marjorie on Jan 8, 2026

No more itching!

My cat was itching and had a fungal thing going on his fur. Took two washes and it's gone and he is much happier. Only downside is the bottle's pump is very sti

My cat was itching and had a fungal thing going on his fur. Took two washes and it's gone and he is much happier. Only downside is the bottle's pump is very stiff.

Rated 4 out of 5 stars
By Carol on Nov 30, 2025

Otis isn't itchy

My poor guy has been scratching and chewing for a fee months. I had tried everything even the groomer tried what she had. I saw the ad for this product and thought

My poor guy has been scratching and chewing for a fee months. I had tried everything even the groomer tried what she had. I saw the ad for this product and thought what do I have to loose. It worked, he finally stopped itching and scratching

Rated 5 out of 5 stars
By Theresa on Dec 13, 2025

My Vet Recommended

I've been using this shampoo for several years on my pitbull. He has allergies and this has helped his fur become much healthier. He hasn't had any hair loss in

I've been using this shampoo for several years on my pitbull. He has allergies and this has helped his fur become much healthier. He hasn't had any hair loss in a long time! I use it on both my dogs weekly.