VETOQUINOL Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count -

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats

By Vetoquinol
Rated 3.9428 out of 5 stars

$31.49Chewy Price
$33.99Chewy Price
$29.92Autoship Price
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About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 75 mg capsules that can be given by mouth, or opened and mixed with a meal.

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Nutritional Information

Feeding Instructions


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Questions & Answers

28 Customer Questions

Can this be given long term for severe anxiety?
Answer by ChewyJan 04, 2018
This Supplement is intended for short term use. Use as recommended by your veterinarian.

I'm moving and am taking my 2 cats and 3 dogs with me.. would this help them for an 18 hour drive?
Answer by ChewySep 20, 2018
This is perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.

Are any of the ingredients made or obtained from China? Where is this manufactured?
Answer by ChewyNov 07, 2019
This product is sourced in Canada and manufactured in the USA.

Is this for dog depression??
Answer by ChewyOct 25, 2017
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs and cats safely and with no tranquilizing or sedating effects.

ReviewsWrite a Review

Rated 3.9428 out of 5 stars
332 Reviews
Would recommend to a friend

332 Customer Reviews

Filter by reviews that mention

Rated 5 out of 5 stars
By CatMom68 on Mar 5, 2023

works like a charm!!

I relocated from Pennsylvania to Georgia with my cat. We were driving 13 hours. I gave her the recommended dose a half hour before we hit the road. She was up for the first half hour and slept most of the 13 hour drive, with the exception of the last hour. She was quiet all the time that she was awake. It kept her very calm. No side effects. I would highly recommend this for anyone considering using this product. She has to go to the vet this week and I’m going to use a smaller dosage for the car ride to the vet as well.

Rated 2 out of 5 stars
By Noelle on Feb 17, 2023

Had opposite effects

I had high hopes for this. We have a sixteen year old miniature schnauzer who has entered the more advanced stages of dementia and as a result experiences anxiety at night. Unfortunately this supplement made him behave like he was on a stimulant. He raced around the house and ran into things, his eyesight is getting bad too, and was up all night. The second day we only gave him half the recommended dose, and the same thing happened. I wanted to avoid giving him drugs from the vet, but it looks like we will have to take that step.

Rated 5 out of 5 stars
By Dogma on Dec 22, 2022

Like flipping a switch

On a weekend I called Chewy and spoke with their Vet about behavior my formerly sweet Jack Russell had begun with his playmate canines. She recommended Zylkene,with a grain of skepticism I ordered that same day. After a week the nipping head butting over aggressive play destructive energy bursts even potty in the house diminished by 75%. Now he loves to learn sits long enough to take part in short training sessions even his play has calmed. I am so grateful for this product and the Vet at Chewy whose advice saved us expensive Vet visits.This is so worth a try Sam who at heart is a loving boy deserves to be happy as his playmates in the home when we feared at times not being able to keep him,once again Chewy delivers in the truest sense. Thanks all around for his product!

Rated 5 out of 5 stars
By Amanda on Jan 5, 2023

Helps our kitty

One of our cats gets stressed easily with any changes in the home, or the presence of stray cats outside. He will lash out at our other cats or had sprayed a couple times in our home. I open one capsule and put it onto his wet food everyday in the morning and it seems to be helping balance him out. There’s been less aggression and he hasn’t sprayed, so fingers crossed!

Rated 4 out of 5 stars
By caseyh on Nov 4, 2022

Subtle change

I have a cat that is a diva by day and a gremlin by night.... Got hyper moments that made her look like she was seeing purple elephants! I got the new litter robot so the bathroom situation changed and in all honesty, she was stressing me and her fur-siblings out. I used to work at a vet clinic when this product became available so knew the product and thought I'd give it a try for my crazy cat to help with any anxiety (along with the feliway diffuser already in use). I gave 4 out of 5 stars because any change is quite subtle, but I think it has been helping her. She hasn't had the psychotic looking moments and acts like a regular 3 yr old cat. I wouldn't recommend this product for anxiety inducing events for pets like thunderstorms or separation anxiety. I would recommend for situations where change is happening in the household: rearranging layout, house guests, new baby, new pet, etc. It is a supporting supplement rather than a treatment for anything.

Rated 5 out of 5 stars
By Atlas on Nov 3, 2022

really works!

i have a shelter cat who has some big fears we're working through and these little pills help her a lot. i shake it up in a puzzle feeder with her dry food in the morning and she has been much happier since starting them. she's more confident, affectionate, and has been better with over-grooming to boot! by all means it has not solved every issue ever, but this is a very helpful tool for her! i plan on keeping her on it for the foreseeable future.

Rated 5 out of 5 stars
By MomsRudy on Oct 28, 2022

Miracle Product

Our vet recommended Zylkene for my 10-year-old dog. Rudy developed separation anxiety. He was attacking us as we were leaving the house. He would lunge at us barking growling and biting. Some days he would jump up and attack us if we walked by the chair he was napping on. The behavior was very disturbing to my husband and me. Rudy is a lot calmer and has stopped acting as upset when we leave. I love a product that is drug free and works without side effects.

Rated 5 out of 5 stars
By Debbie on Dec 2, 2022

Great for peeing problem!

Our cat has been peeing all over the house ever since we got our new kitten. We've done all of the medical workups and it is definitely behavioral. A friend, who is a vet tech, recommended this product and she has not peed out of her litter box since starting it! It is the wonder drug!

Rated 5 out of 5 stars
By rescuemom on Sep 11, 2022

Jury is still out...

My pup is virtually blind having lost an eye and has advanced and inoperable cataracts in the other. As his vision has decreased his anxiety has begun to increase. We are trying a low dose of Zylkene because the other anti-anxiety chew that worked for him was just too hard to have him take. He started with the dose for a medium dog, but it was too much. He was very lethargic. We are finding the small dog dose just right, although he is a picky eater so feeding it with a meal is tricky when he chooses not to eat. However, his appetite is getting better on Zylkene. It is worth a try!

Rated 1 out of 5 stars
By CatsMama3 on Mar 5, 2023


It didn't make noticable difference in my cat's anxiety, sadly.