Advantage II Flea Spot Treatment for Cats, over 9 lbs

By Advantage II
Rated 4.2287 out of 5 stars

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$16.98Chewy Price
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: (S)-Methoprene: 4.05%, Etofenprox: 45.00%.Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%Dinotefuran, Fipronil and PyriproxyfenActive Ingredients: Fipronil 9.8%, (S)-Methoprene 11.8%.
LifestageAdultKitten, Adult, SeniorAdultKitten, Adult, SeniorAdult
Small Pet TypeFerret

About This Item


  • Flea protection for cats weighing over 9 pounds, at least 8 weeks of age.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

See More





Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Questions & Answers

33 Customer Questions

Since the product is applied to your cats neck, what about the fleas on the cats belly will they move to the neck?
Answer by ChewySep 19, 2017
The active ingredients of Advantage II work to attack the fleas, no matter where they're located on your cat.

can you use before 30 days is up
Answer by ChewyMay 15, 2021
Under normal conditions this product is effective for one month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

If my cat weighs about 9 lbs on the dot, which treatment should I use?
Answer by ChewyMay 24, 2019
If your cat weighs 9 pounds, it's recommended to use the Advantage II Flea Treatment for Small Cats 5 to 9 pounds. Use this treatment if they're over 9 pounds.

Do indoor cats need this?
Answer by ChewyMar 07, 2019
It is generally recommended to treat indoor pets. Fleas may be introduced into the home by coming in on another pet or even onto a person. If you are uncertain, we recommend consulting with your veterinarian who is familiar with flea information for your specific location.

ReviewsWrite a Review

Rated 4.2287 out of 5 stars
2715 Ratings
Would recommend to a friend

2676 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Erma on Nov 30, 2023

No longer works

I have been using this product for the last 4 years. It used to last about 20 days and then stopped working. This latest batch I bought from Chewy which are 2 boxes of this bigger size for my rescue cats does not work at all. I also bought 2 boxes for my smaller cats. I first treat every cat with Capstar and then the next day use this Advantage II. The next day after using this product, there were fleas back on every cat that was treated. It clearly says on the box that it kills fleas and it did not kill them as promised. I am so disappointed because that is $56 a box for 6 doses. I bought 2 of this size box and 2 boxes of the smaller cat size. That is $224.00 plus tax I am out of because this product does not work! I want my money back!!!!! Can anyone please help me? Thanks

Rated 1 out of 5 stars
By worried on Oct 29, 2023


A vet had given me Advantage II a year & a half ago. Worked fine, so I started buying it through Chewy to save a few dollars. Never had an issue with my boy. He didn't like getting a monthly application but also didn't get fleas. I put the last application in the box on him today, and within 15 minutes, I noticed muscle tremors. His neck and head are shaking, he's lethargic, and almost acting drugged. This has never happened before with this medicine! I've called the vet, and they instructed me to wash the application site with soap & water and bring him in if his condition worsens. Of course, I've found others online talking about Advantage II making their cats sick and even some reports of death. We are praying our boy will be alright and pull through, but DO NOT USE ADVANTAGE II! The risk to your pet's well-being isn't worth a moderately priced poison made by the Bayer company !

Rated 5 out of 5 stars
By Nancy on Nov 1, 2023

Fleas Be Gone

Four cats, who only go to the veterinarian and live only on the second floor of my house, got fleas at the veterinary clinic. Since the pandemic, we can't go in with them. And now because on Sundays they do TNR, we still can't go in. So, feral cats are there as my cats once were. Memories of a flea problem for my indoor domestic cats in the 1980s, when I took in a lost cat came back. Trying to give flea baths at home, where the fleas went around the cat's eyes and jumped off my cat at me and having to flea bomb the apartment. No More! Just put Advantage II on them as directed, keep them from licking each other for 24 hours. Vacuum every corner. Put all the their bedding in the dryer on high at least for 30 minutes and no live fleas so far. I will keep this up for several months to a year. Flea larva will spin a pupa, which is like a cocoon. The pupa is very hard and has a sticky outer coating that helps it hide deep in carpets and fabrics. The pupa stage can last as little as a week or up to a year. Here's where I have to try out my new steam cleaner as steam will kill everything in the corners and the carpets on the floor and the cat trees.

Rated 5 out of 5 stars
By Gretchen on Nov 30, 2023

Great flea medicine

I’ve been trying to get rid of fleas on my cats for 6 months, trying safer versions and comparable meds and this has been the only medicine that has worked so far. They are currently only their 3rd month of using Advantage and I will continue using this in the future. We got rid of the fleas when they got on the Advantage.

Rated 5 out of 5 stars
By 1starfish2 on Nov 4, 2023
Top 1000 Contibutor

It works!

I have been using Advantage for many, many years and can attest that it is truly an effective product (it is important not to skip a month, though). I have found that even my squirmiest cats throughout the years have tolerated this medication well since it requires just a quick little squirt to their nape. Of course it does leave a temporary medicinal smell, but offering a treat afterward seems to help ease any distress. And, thanks to this product, no flea problems!

Rated 1 out of 5 stars
By JessicaB on Oct 22, 2023


Have been battling fleas using Advantage for 5 months without success. After talking to my vet I was told most fleas are becoming immune to the active ingredients in Advantage, making it much less affective. Switched to a product with the active ingredient as Selamectin and fleas are officially eradicated 2 weeks later. Although selamectin is rx only, it's definitely worth it and is typically cheaper! Don't waste your time and money on Advantage.

Rated 2 out of 5 stars
By Carol on Nov 27, 2023

Not happy

I am disappointed with the Advantage flea spot. It does not work well for my Cat. It’s been on since Oct. 15th, He still scratches little fleas up and out. I also have the flea light traps around. Is there some better than Advantage.

Rated 1 out of 5 stars
By Daniel on Oct 23, 2023

Big waste of money!

After applying this flee treatment there has not been any relief for my cats. The flees still there after a week since the application. I only gave it a one star review just because there was not a big zero as a review!! I spent 200 plus for the flee treatment and the deworming pills which I have not been able to give to them since we still have the flee problem. Definitely would not buy it again.

Rated 4 out of 5 stars
By Helena on Nov 20, 2023

advantage for cat over 8 lb.

My new baby came from Human Society with fleas. They treated him but it did not go away. I was giving him other bought from Chewy, did not work. My 5 yrs old F got the fleas from the kitty but not many. It looked the advantage worked. but not 100 %.

Rated 5 out of 5 stars
By sandra on Nov 24, 2023

The Advantage works great on them. Was getting a different kind and always had to chase them down to apply it, but with the Advantage they don't run and hide so it must not irritate their skin. I think the other did.