Advantage II Flea Spot Treatment for Cats, over 9 lbs

By Advantage II
Rated 4.3371 out of 5 stars
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 1 Dose (1-mo. supply) slide 1 of 12
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 1 Dose (1-mo. supply) slide 1 of 12

$15.99Chewy Price
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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing over 9 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 2, 4 or 6 treatments.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Dinotefuran, Fipronil and PyriproxyfenActive Ingredients: (S)-Methoprene: 4.05%, Etofenprox: 45.00%.
LifestageAdultAdultAdult, Kitten, SeniorAdult, Kitten, SeniorAdult
Small Pet TypeFerret

Questions & Answers

34 Customer Questions

How many treatments in box?
Answer by ChewyJun 03, 2021
This product is available in single doses, 2, 4 or 6 dose treatment boxes.

Do the fleas haveto bite my cat to die or do they die on contact
Answer by ChewyDec 06, 2021
This treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required.

Since the product is applied to your cats neck, what about the fleas on the cats belly will they move to the neck?
Answer by ChewySep 19, 2017
The active ingredients of Advantage II work to attack the fleas, no matter where they're located on your cat.

Do I have to treat for fleas all year, I live in TN?
Answer by ChewyAug 26, 2017
One convenient application of Advantage II cat flea treatment keeps working for 1 month. If your cat still has fleas after the 1 month, we'd recommend treatment for another month until the fleas are gone.

ReviewsWrite a Review

Rated 4.3371 out of 5 stars
2329 Reviews
Would recommend to a friend

2329 Customer Reviews

Rated 5 out of 5 stars
By Kayla on Aug 7, 2022

vet recommend this product to me

Works just fine. Because of how flea cycles work you need to be consistent with this product (or any flea product) to ensure that it is working properly. It can sometimes take years to completely get rid of fleas in the house. You can’t use flea products one time or every once in a while and expect them to work. Also if you have strictly indoor cats, but have dogs, the fleas will will still come inside on the dogs even if they are on flea and tick medication.

Rated 5 out of 5 stars
By daria200 on Jul 19, 2022

Prevented an infestation

I had found flea dirt on my white sheets when I brought home my new foster cat. After finding a handful of live fleas on him, I administered Advantage II on him and continued to comb him twice a day. Managed to find 2 more dying fleas in the next 2 days after that and no more flea dirt. I'm convinced that timely administration of this treatment prevented what could have been a flea infestation that would have been a huge headache.

Rated 1 out of 5 stars
By Daniel on Aug 1, 2022

Relentless Fleas!

I keep ordering this product because it is the best of all the rest of the non Prescription products but it’s only okay. It does not kill all the fleas or nymphs, eggs. Even with repeated washing of bedding’s and constant vacuuming and yard treatment they are still here. Perhaps the fleas have built up an immunity? I will keep trying but can not say you will receive the results you are wanting.

Rated 1 out of 5 stars
By Snowwkat on Jul 27, 2022

Not what they Claim!!!

This is not what they Claim!!! I used this on my 4 cats and they still have fleas it is almost like it drew more fleas to them! {:/. I am now ,still trying to find some thing else that will rid these things from my Cats, so my Cats don't have to suffer. I mean every time I turn around my Cats are itching and biting rrrrrrrrr my poor babies are suffering so I'm still looking for something else

Rated 5 out of 5 stars
By Sadie on Jul 1, 2022

Better than Frontline

Thank goodness for this. I adopted a second cat and despite supposedly having been treated at the cat rescue for fleas, the new cat brought home fleas. By the time I noticed something was wrong it was really bad. I tried Frontline on both cats first because that's what the rescue had given me, but it only reduced the flea activity maybe 50 percent. I had to wait 30 days before I could treat them again and decided to switch to Advantage 2. Once I used it, I never saw a flea on the cats or in my home ever again. I wish someone would have just told me that this stuff is superior, that killing the flea eggs and killing adult fleas within 12 hours is superior to Frontline's formula. Go straight to this stuff.

Rated 1 out of 5 stars
By Annoyed on Jul 26, 2022

Terrible Product

I have used this multiple times over the last year in hopes that one attempt will work. My cats have suffered with fleas since they were kittens (they are almost 3) and we have tried Advantage multiple times with no luck. This has also been done in conjunction with cleaning and fumigating the whole house, so there is nothing to blame but this falsely-advertised product.

Rated 5 out of 5 stars
By Chellie on Jul 28, 2022

Best flea treatment I've ever used!!!

I've tried so many other spot treatments and this one is by far the best!! I put it on my cat and by the next morning I noticed a HUGE difference in her!! She was much much calmer and she wasn't scratching or licking at all!! I will definitely be using this one on her every month!

Rated 5 out of 5 stars
By MoofyandFreaky on Aug 5, 2022

Moofy and Freaky like Advantage II

It always works for us. It is quick and easy to order and get your meds or flea treatments within just a few days. For flea treatments it is easier than searching through all of the stores in town and finding that they may or may not have it in stock.

Rated 1 out of 5 stars
By 1946JW on Jul 13, 2022

Does Not Work

I purchased Advantage several times this year from Chewy the last time and from my vet before. It has not worked for the last three times I have used it. My cats have continued to suffer. I have been flea combing them every day. With 11 inside cats, this is no easy job. I also tried flea collars with no luck. I will not buy Advantage again.

Rated 5 out of 5 stars
By Littlebit on Jul 15, 2022

Fleas on my cats

Loved it, loved it. Fleas gone and house good. I can always depend on it getting here fast. My little bit and I was surprised when she received a birthday card on her birthday no other company has ever did this. This just showed how caring they are for their animal clients. Thank you again Chewy for caring.