ADVANTAGE II Flea Spot Treatment for Cats, 5-9 lbs, & Ferrets, 1 Dose (1-mo. supply) -

Advantage II Flea Spot Treatment for Cats, 5-9 lbs, & Ferrets

By Advantage II
Rated 4.2389 out of 5 stars
Pet Weight

$16.98Chewy Price
$16.13Autoship Price
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About This Item


  • Flea protection for small cats weighing 5 to 9 pounds, at least 8 weeks of age.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

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Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Questions & Answers

28 Customer Questions

Since the fleas do not have to bite my cat to be killed do they have to crawl over the specific application site to be killed?
Answer by ChewySep 07, 2017
This product doesn't require fleas to bite for it to take effect but it must come into contact with the pest.

Is this safe for Nursing cats? If so will it also protect the newborn kittens from fleas?
Answer by ChewyJul 26, 2017
As with any product, it's best to consult your veterinarian before using this product on pregnant or nursing cats.

how many cc are in one application tube?
Answer by ChewyAug 04, 2018
Each application tube contains 0.4 cc.

Does Advantage 2 protect against mosquitoes also?
Answer by ChewyJun 16, 2018
This product has not been tested to repel mosquitoes.

ReviewsWrite a Review

Rated 4.2389 out of 5 stars
1105 Ratings
Would recommend to a friend

1105 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By cindy on May 6, 2023

Advantage 11

I've used this for 25 years and never had a problem with fleas. It is compatable with the advantage ll for dogs. . Frontline stopped working years ago but this is all I use now. Don't understand why people says it doesn't work. I have 3 dogs and 4 cats that go in and out and never had a flea infestation. If cats are full of fleas make sure you comb them well to get them off then apply. Should be used before the flea season starts for best results. Remember the fleas have a cycle so give it a chance to work.

Rated 5 out of 5 stars
By Barb on Apr 28, 2023

Like Advantage II

This flea treatment is perfect for small cats. We use the larger size for Been using Advantage II for many years on my cats. I like that they have the small size for our little cat only 8 pounds. We use the larger size on our 10 pound cat also. This product works great. We’ve not had any problems with fleas since using Advantage. It’s easy to apply and our cats have never had any adverse reactions to it. The Chewy price is great too. Have auto ship set up so never need to worry about having it when it’s time to treat my cats.

Rated 2 out of 5 stars
By mads on Apr 14, 2023

your mileage may vary

it seemed to work pretty well at first, but the fleas in new orleans are brutal. one of our cats will run out the door about once a week, and we always get him within a few minutes. doesn't matter-- both cats and house are COVERED in fleas even with combing and giving them more meds a few weeks later. if you live somewhere where the fleas aren't too bad, it will probably work just fine. may just have to stick to seresto collars.

Rated 1 out of 5 stars
By CatMama on May 3, 2023

Not that effective.

I bought this for my two cats & my shorthaired tabby cat is STILL itching fiercely after having this on for at least a week! Longhaired cat was not getting eaten alive as much as my poor tabby. I am going to get something else directly from my vet next time.

Rated 5 out of 5 stars
By buckroth on Feb 19, 2023

Effective and Well Tolersted

This is my go-to product when the fleas threaten to take over. The house we rent previously had cats inside and out. The fleas initially were overwhelming our indoor cats. We finally had to dose our cats 7 days apart before settling into the monthly routine. All our cats barely register when we apply their monthly dose. I know that some cats will react strongly and even get sick, but in the 2 decsdes we've been rehoming stray and dumped cats, none of them have ever gotten sick from the application of this product. Some of our cats were dealong with other issues but still tolerated this product well. I can recommend it's worth a try if you're willing to stick to 3-4 monthly application schedule to break the flea life cycle.

Rated 4 out of 5 stars
By Ralf5k on Apr 22, 2023

Too expensive

I couldn't give you 5 stars only because of the price. I am caring for many cats including ferals on a fixed income, makes it tough to make ends meet. Aside from the price, you have done your usual outstanding job.

Rated 4 out of 5 stars
By dino on Apr 29, 2023

flea defense

So far so good, haven't seen cats scratching since I used Advantage. Been using Advantage for cats 10lbs but now have a new cat under that weight so this is first encounter with Advantage 5-9 lbs

Rated 2 out of 5 stars
By Catmimi on May 24, 2023

Flea and ticks

Catmimi had applied the advantage, two days later I saw her scratching again. I think this medication does have certain effect but not last long.

Rated 1 out of 5 stars
By Shiloh on Mar 3, 2023

Did Not Work !

We do not have fleas anywhere else except on our cat and 10 days after treatment I am still finding full grown fleas actively crawling on and biting her. Also it gave her diarrhea which was not fun for anyone. I have used other products that were immediately effective. Someone thought I was just being cheap but no it actually worked best.

Rated 3 out of 5 stars
By Mo on May 19, 2023

Not for ticks

Unfortunately this is only for fleas & not ticks, my error, I was searching flea & tick medicine and didn’t look close enough