Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)

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$68.98 Chewy Price
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About This Item

Details

  • Flea protection for cats weighing over 9 pounds, at least 8 weeks of age.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

Ingredients

Instructions

Size

FAQ

Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II for Cats

Get the Advantage Over Fleas

Advantage II topical flea treatment and prevention for cats kills fleas on your cat within 12 hours, and it continues to protect for 30 days. It’s easier to use than hard-to-swallow pills—simply apply the convenient flea drops directly to your cat's skin once a month. Best of all, Advantage II is available without a prescription.

Flea Treatment and Prevention

Advantage II doesn't just treat fleas––it breaks the flea lifecycle to prevent reinfestation.

Works Through Contact

These flea drops kill adult fleas, flea larvae, and flea eggs through contact, so they don't have to bite your cat to die.

Same-Day Effectiveness

Advantage II starts killing fleas on cats within 12 hours, and it continues to prevent reinfestations for four weeks.

No Prescription Needed

You don’t have to go to the vet to get quality flea protection for your cat—simply buy and apply.

Fragrance-Free

This flea topical formula is fragrance-free and waterproof 24 hours after application.

Frequently Asked Questions

Can I Use Advantage II on My Cat?

Advantage II is for cats and kittens 8 weeks of age and older. It comes in three sizes: Kitten (2-5 lbs.), Small Cat (5-9 lbs.), and Large Cat (9+ lbs.). Choose the right size based on your pet's weight. Advantage II for cats is suitable for both indoor and outdoor cats, but not for use on dogs.

How Do I Apply Advantage II?

Once you break the seal on the tube, part the hair at the base of your cat’s skull until the skin is visible. Squeeze the tube to expel the entire contents directly onto the skin in that one spot. Do not get this product in your cat’s eyes or allow your cat to ingest it.

The Advantage Family

Get the Advantage over fleas with complete flea protection for your pet, home, and yard. The Advantage family of products has everything you need for a complete flea treatment and prevention plan, including monthly topical treatments, pet shampoos and sprays, household sprays for carpets and crevices, and even a yard and premise spray. Just be sure to get the right product for each need and use only as directed.

Shop K9 Advantix II

Compare Similar Items

Advantage II
Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II
Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
$68.98 Chewy Price
($11.50/ea)
Rated 4.5 out of 5 stars
9.7KReviews
Health Feature         
Anti-Parasitic
Anti-Parasitic
Anti-Parasitic, Pest Control
Anti-Parasitic, Pest Control
Made In         
United States
United States
Sourced From         
United States
United States
Ingredients         
Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.
Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.
Dinotefuran, Pyriproxyfen.
Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.
Dinotefuran, Pyriproxyfen.
Dinotefuran, Fipronil and Pyriproxyfen
Active Ingredients: Fipronil 9.8%, (S)-Methoprene 11.8%.
Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%
Active Ingredients: Fipronil, (S)-methoprene.
Fipronil + (s)-Methoprene
Repels or Prevents         

Questions & Answers

41 Customer Questions


Since the product is applied to your cats neck, what about the fleas on the cats belly will they move to the neck?

Answer by ChewySep 19, 2017
The active ingredients of Advantage II work to attack the fleas, no matter where they're located on your cat.

can you use before 30 days is up

Answer by ChewyMay 15, 2021
Under normal conditions this product is effective for one month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

If my cat weighs about 9 lbs on the dot, which treatment should I use?

Answer by ChewyMay 24, 2019
If your cat weighs 9 pounds, it's recommended to use the Advantage II Flea Treatment for Small Cats 5 to 9 pounds. Use this treatment if they're over 9 pounds.

Do indoor cats need this?

Answer by ChewyMar 07, 2019
It is generally recommended to treat indoor pets. Fleas may be introduced into the home by coming in on another pet or even onto a person. If you are uncertain, we recommend consulting with your veterinarian who is familiar with flea information for your specific location.

4.5
Rated 4.5 out of 5 stars
9705 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

82% Positive

Effectiveness

81% Positive

Ingredients

79% Positive

Long-Term Benefits

82% Positive

4295 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Karen on Oct 14, 2025

Total nuisance control

I used to use front line and all my animals doesn’t work anymore. I think the animals have become immune to it or the ticks and fleas are but Iuse advantage now

I used to use front line and all my animals doesn’t work anymore. I think the animals have become immune to it or the ticks and fleas are but Iuse advantage now don’t have a problem. I never had a problem and I don’t plan on having more problems, I’m faithful every month. I ordered boxes a year And I’m on top of it. Thanks. Chewy great prices


Rated 1 out of 5 stars
By Jay on Oct 17, 2025

Allergic Reaction

Even though Sunny has had this flea medicine before he had an allergic reaction. Thankfully it wasnt too bad but the vet told me its common for cats to have allergic

Even though Sunny has had this flea medicine before he had an allergic reaction. Thankfully it wasnt too bad but the vet told me its common for cats to have allergic reactions to this flea medicine. If you use this medication I would recommend keeping a close eye on your cat before committing to using it again.


Rated 5 out of 5 stars
By Cynthia on Sep 16, 2025

22lb Monster of Cat

I use this for my extra-large cat. My smaller cats have been using a different brand. I see fleas come back on them after about 3 weeks from application. This one

I use this for my extra-large cat. My smaller cats have been using a different brand. I see fleas come back on them after about 3 weeks from application. This one has been lasting 4-5 weeks, even with fleas starting to get on the others. The price on this one was better than the other main brands for large cats. I will be buying again, but adding the lower weight doses too for the smaller ones.


Rated 3 out of 5 stars
By Elsie on Sep 9, 2025

Still found a few fleas

After still finding a few fleas I switched away. There were three weeks to go before I could put drops on them again, so continued flea combing, marinating my

After still finding a few fleas I switched away. There were three weeks to go before I could put drops on them again, so continued flea combing, marinating my small condo yard in diatomaceous earth, gave each cat a Capstar, yet again and again with the deep vacuuming and laundry! All that and the Capstar seemed to break it. A week and a half ago each kitty was treated with Advantage II. All seems to be well but I’m keeping my eyes open!


Rated 5 out of 5 stars
By Karen on Sep 23, 2025

Effective flea treatment

We like this flea treatment. It works. Yuki spends much of each day out in our garden, so he needs it. He is not a fan of having it applied. One of us has to hold

We like this flea treatment. It works. Yuki spends much of each day out in our garden, so he needs it. He is not a fan of having it applied. One of us has to hold him and pet him, while the other tries to part his very thick fur, to get to the skin. A difficult feat. Then the fluid is applied to the skin. He dislikes this, but we tell him that it has to be done, and give him some more pets.


Rated 1 out of 5 stars
By DSS on Sep 20, 2025

You are gambling if you give this medication to your cat!

We gave this medication to three large cats, two of the three cats started having severe tremors and could barely walk. The vet says they see this all the time,

We gave this medication to three large cats, two of the three cats started having severe tremors and could barely walk. The vet says they see this all the time, and you're much better off giving your cat oral medication prescribed by the vet. Good luck if you use this medication!


Rated 2 out of 5 stars
By Suzanne on Sep 2, 2025

Package Arrived OPEN

I was surprised to find the Advantage II box open after I removed the other items I ordered and the wrapping paper from the shipping box. The perforation on the

I was surprised to find the Advantage II box open after I removed the other items I ordered and the wrapping paper from the shipping box. The perforation on the box was completely open before I even touched the box. All six treatment packages were inside and appear to be intact. However, I expected to receive a new unopened box after paying the full price for one.


Rated 5 out of 5 stars
By Robbie on Sep 28, 2025

Fast delivery

Chewy always has super fast delivery which is the best. It always comes within 1-2 days. The only downside is they make you think you save so much with autoship

Chewy always has super fast delivery which is the best. It always comes within 1-2 days. The only downside is they make you think you save so much with autoship so you sign up but you really don't. Ive saved 70$ in almost 4 years. I've spent almost over 1,000$.


Rated 1 out of 5 stars
By Sharon on Oct 10, 2025

Flea Medicine arrived Opened

Not the product, but how it was shipped. It was placed in the box first with a box of litter and a bag of food placed on top. Box arrived opened and crushed.

Not the product, but how it was shipped. It was placed in the box first with a box of litter and a bag of food placed on top. Box arrived opened and crushed.


Rated 1 out of 5 stars
By Angelina on Aug 31, 2025

Ineffective compared to other products.

I began using this after seeing my cats lose their hair due to fleas, however even after 6 months I saw no dent in the flea population. As per instructed on the

I began using this after seeing my cats lose their hair due to fleas, however even after 6 months I saw no dent in the flea population. As per instructed on the box, I even gave my pets an early application to control the fleas more. I treated my home and lawn for fleas as well. However even doing this did not fully work. Only after going to my local vet and asking for a recommendation did I finally receive a product that actually worked within DAYS. Not weeks, not months, DAYS. The vet even said that this product is inferior. We use NexGard Combo now. It costs more, but its better than wasting my money on something that didnt help. I've spent hundreds I will never get back. My family had used this product in the past, and it seemed to work fine. My cats didn't even have that severe of a flea infestation. Maybe the quality of this product has gone down, I don't know either way I'm upset I didn't write the review sooner.