10 Best Cat Anxiety Supplements 2025: According to Reviews | Chewy

The 10 Best Cat Anxiety Supplements

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How we created this cat anxiety supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best cat anxiety supplement.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best cat anxiety supplements.

Key cat anxiety supplement considerations

Dosage

Effectiveness

Ingredients

Side Effects

1
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch

Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch

Rated 4.1 out of 5 stars
1,643
$14.99Chewy Price
($4.06/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Side Effects

4.0/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Thiamine (Vitamin B1), L-Theanine, Chamomile , Inactive Ingredients: Thiamine (Vitamin B1), L-Theanine

Special Diet

Natural, No Corn No Wheat No Soy

Food Flavor

Chicken
2
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4.1 out of 5 stars
1,578
$18.74Chewy Price
($0.94/mL)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

HPUS 5x Dilution of Helianthemum Nummularium, Clematis Vitalba, Impatiens Glandulifera, Prunus Cerasifera, Ornithogalum Umbellatum

Special Diet

Natural
3
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Rated 4.4 out of 5 stars
442
$9.99Chewy Price
($10.90/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

3.8/5
Good

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Side Effects

3.8/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Catnip and Silvervine

Material

Plant Material

Special Diet

Natural
4
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Rated 4.1 out of 5 stars
743
$35.99Chewy Price
($1.20/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.2/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin

Health Feature

Calming
5
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag

Sentry Calming Chews Supplement for Cats, 4-oz bag

Rated 4.2 out of 5 stars
642
$9.94Chewy Price
($2.49/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

Adult, All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Brown Rice Flour, Chicken Fat, Chicken Meal

Special Diet

No Corn No Wheat No Soy

Food Flavor

Chicken
6
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rated 4.2 out of 5 stars
36
$12.84Chewy Price
($3.48/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.6/5
Excellent

Side Effects

4.4/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Chicken Fat, Chicken Meal, Citric Acid

Food Flavor

Chicken

Packaging Type

Bag
7
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

Rated 4 out of 5 stars
148
$25.97Chewy Price
($6.50/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.0/5
Great

Side Effects

4.2/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Thiamine, L-Tryptophan, Hemp Seed Oil, Chamomile Extract, Valerian Extract

Food Flavor

Unflavored
8
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag

Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag

Rated 4.1 out of 5 stars
141
$11.43Chewy Price
($1.91/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Side Effects

3.8/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Salmon, Chickpeas, Pea Flour, Lentils, Vegetable Glycerin

Special Diet

Grain-Free

Food Flavor

Seafood & Fish, Salmon
9
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count
Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count

Real Mushrooms Mushroom Relax Soft Chew Calming Supplement for Dogs & Cats, 60 count

Rated 4.1 out of 5 stars
20
$44.90Chewy Price
($0.75/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Side Effects

4.3/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Food Flavor

Bacon, Chicken, Liver

Packaging Type

Tub
10
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar
Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar

Raw Paws All-Natural Loose Leaf Cut Catnip for Cats, 1-oz jar

Rated 4.4 out of 5 stars
73
$10.99Chewy Price
($10.99/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.0/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.3/5
Great

Side Effects

3.9/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

Adult, All Lifestages

Top Ingredient

Catnip

Special Diet

Grain-Free, Gluten Free, No Corn No Wheat No Soy

Food Flavor

Catnip