10 Best Cat Anxiety Supplements 2025: According to Reviews | Chewy

The 10 Best Cat Anxiety Supplements

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How we created this cat anxiety supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best cat anxiety supplement.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best cat anxiety supplements.

Key cat anxiety supplement considerations

Dosage

Effectiveness

Ingredients

Side Effects

1
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count
Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count

Purina Pro Plan Veterinary Diets Calming Care Cat Supplement, 30 count

Rated 4.3 out of 5 stars
1,016
$33.99Chewy Price
($1.14/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Side Effects

4.2/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

Adult, All Lifestages

Top Ingredients

Bifidobacterium Longum, Vitamin E, Liver Flavor, Maltodextrin

Food Flavor

Liver, Unflavored
2
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch

Pet Honesty Dual Texture Chicken Flavored Calming Chews for Cats, 3.7-oz pouch

Rated 4.1 out of 5 stars
1,521
$14.99Chewy Price
($4.06/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Side Effects

4.0/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Thiamine (Vitamin B1), L-Theanine, Chamomile , Inactive Ingredients: Thiamine (Vitamin B1), L-Theanine

Special Diet

Natural, No Corn No Wheat No Soy
3
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4.1 out of 5 stars
1,518
$18.74Chewy Price
($0.94/mL)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.2/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

HPUS 5x Dilution of Helianthemum Nummularium, Clematis Vitalba, Impatiens Glandulifera, Prunus Cerasifera, Ornithogalum Umbellatum

Special Diet

Natural
4
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Rated 4.4 out of 5 stars
403
$9.99Chewy Price
($10.90/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

3.7/5
Good

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Side Effects

3.7/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Catnip and Silvervine

Material

Plant Material

Special Diet

Natural
5
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Rated 4.1 out of 5 stars
712
$35.99Chewy Price
($1.20/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin

Health Feature

Calming
6
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag

Sentry Calming Chews Supplement for Cats, 4-oz bag

Rated 4.2 out of 5 stars
534
$9.94Chewy Price
($2.49/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

Adult, All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Brown Rice Flour, Chicken Fat, Chicken Meal

Special Diet

No Corn No Wheat No Soy

Food Flavor

Chicken
7
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rated 4.2 out of 5 stars
29
$12.84Chewy Price
($3.48/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.7/5
Excellent

Side Effects

4.4/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Chicken Fat, Chicken Meal, Citric Acid

Food Flavor

Chicken
8
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag

Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 6-oz bag

Rated 4.2 out of 5 stars
104
$11.43Chewy Price
($1.91/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Side Effects

3.9/5
Good

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Salmon, Chickpeas, Pea Flour, Lentils, Vegetable Glycerin

Special Diet

Grain-Free
9
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

Rated 4 out of 5 stars
139
$25.97Chewy Price
($6.50/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.1/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Thiamine, L-Tryptophan, Hemp Seed Oil, Chamomile Extract, Valerian Extract

Food Flavor

Unflavored
10
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle

+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle

Rated 4 out of 5 stars
21
$45.99Chewy Price
($24.73/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Side Effects

4.3/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Inactive Ingredients: Natural Flavor, Organic Extra Virgin Olive Oil, Quillaja Saponaria

Special Diet

Non-GMO, Gluten Free, Vegan