Best Cat Anxiety Supplements 2026: According to Reviews | Chewy

Best Cat Calming Supplements

How we created this cat anxiety supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best cat anxiety supplement.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best cat anxiety supplements.

Key cat anxiety supplement considerations

Dosage

Effectiveness

Ingredients

Side Effects

Our Top Picks

1
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4.2 out of 5 stars
1,959
$15.93 Chewy Price
($0.80/mL)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Side Effects

4.2/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

**Active Ingredients:** Each 5X (HPUS): Rock Rose (Helianthemum nummularium), Clematis (Clematis vitalba), Impatiens (Impatiens glandulifera), Cherry Plum (Prunus cerasifera), Star of Bethlehem (Ornithogalum umbellatum)

Special Diet

Natural
2
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle
Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Meowijuana Purrple Passion Catnip & Silvervine Blend Catnip, 0.917-oz bottle

Rated 4.5 out of 5 stars
657
$9.99 Chewy Price
($10.90/oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Dosage

3.6/5
Good

Effectiveness

4.2/5
Great

Ingredients

4.4/5
Great

Side Effects

3.8/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Catnip and Silvervine

Material

Plant Material

Special Diet

Natural
3
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag
Sentry Calming Chews Supplement for Cats, 4-oz bag

Sentry Calming Chews Supplement for Cats, 4-oz bag

Rated 4.2 out of 5 stars
1,316
$10.56 Chewy Price
($2.64/oz)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

Adult, All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Brown Rice Flour, Chicken Fat, Chicken Meal

Special Diet

No Corn No Wheat No Soy

Food Flavor

Chicken
4
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch
Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch

Pet Honesty Dual Texture Chicken Flavored Chew Calming Supplement for Cats, 3.7-oz pouch

Rated 4.2 out of 5 stars
2,500
$14.99 Chewy Price
($4.06/oz)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.0/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.2/5
Great

Side Effects

4.0/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Thiamine (Vitamin B1), L-Theanine, Chamomile , Inactive Ingredients: Thiamine (Vitamin B1), L-Theanine

Special Diet

Natural, No Corn No Wheat No Soy

Food Flavor

Chicken
5
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Rated 4.1 out of 5 stars
1,007
$30.39 Chewy Price
($1.02/ea)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.1/5
Great

Side Effects

4.0/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine). Inactive Ingredients: Maltodextrin, Hypromellose (capsule), Magnesium Stearate, Water, Calcium Carbonate

Health Feature

Calming
6
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag
Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rocco & Roxie Supply Co. Chicken Flavored Calming Chew Supplement for Cats, 3.7-oz bag

Rated 4.3 out of 5 stars
195
$11.54 Chewy Price
($3.12/oz)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Side Effects

4.2/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages

Top Ingredients

Barley Flour, Brewers Dried Yeast, Chicken Fat, Chicken Meal, Citric Acid

Food Flavor

Chicken

Packaging Type

Bag
7
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops
HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops

HomeoPet Feline Anxiety Relief Cat Supplement, 450 drops

Rated 4 out of 5 stars
463
$19.49 Chewy Price
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.1/5
Great

Side Effects

4.2/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Aconitum Nap, Arg Nit, Arsenicum Alb, Gelsemium, Avena

Food Flavor

Unflavored

Packaging Type

Bag
8
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle
NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle

NaturVet Quiet Moments with Hemp Seed Oil Bacon Flavored Calming Supplement Drops for Dogs & Cats, 4-fl oz bottle

Rated 4.1 out of 5 stars
203
$26.97 Chewy Price
($6.75/fl oz)
Promo, Save 50% today with Autoship

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.0/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per 1 mL: Thiamine, L-Tryptophan, Hemp Seed Oil, Chamomile Extract, Ginger Extract

Food Flavor

Unflavored
9
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag
Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag

Get Naked Calming Health Grain-Free Salmon & Cheese Flavor Crunchy Cat Treats, 2.5-oz bag

Rated 4.1 out of 5 stars
390
$6.25 Chewy Price
($2.50/oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.1/5
Great

Ingredients

4.2/5
Great

Side Effects

3.6/5
Good

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Salmon, Chickpeas, Pea Flour, Lentils, Vegetable Glycerin

Special Diet

Grain-Free

Food Flavor

Seafood & Fish, Salmon
10
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle
Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle

Zesty Paws 30 Day Starter Kit Calming Diffuser for Cats, 1-fl oz bottle

Rated 4.1 out of 5 stars
89
$34.97 Chewy Price
($34.97/fl oz)
Promo, Save 30% with code SUMMER30

Our ratings

Dosage

3.8/5
Good

Effectiveness

4.2/5
Great

Ingredients

4.1/5
Great

Side Effects

4.1/5
Great

Is this cat anxiety supplement right for my pet?

Lifestage

All Lifestages

Top Ingredients

Feline Facial Pheromone F3 - 4%, Fragrance Orchid Mist - 8%, Isopropylidene Glycerol - 88%

Health Feature

Calming