10 Best Dog Hot Spot Spray & Creams 2026: According to Reviews | Chewy

The 10 Best Dog Hot Spot Spray & Creams

Persistent scratching can quickly lead to irritated skin or hot spots. Topical sprays and creams are often used to soothe discomfort and protect the affected area. When choosing treatments for hot spots, ingredient safety, and ease of application matter just as much as short-term relief. Severe itch or spreading irritation should always be checked by a veterinarian. Below, you'll find today's best-selling and top-rated dog hot spot sprays & creams that Chewy pet parents, like you, love. We update this list every week, so you can be sure you're getting the timeliest product recommendations available.

Our Top Picks

How we created this dog hot spot spray & cream list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best dog hot spot spray & cream.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best dog hot spot spray & creams.

Key dog hot spot spray & cream considerations

Effectiveness

Skin and Coat Health

Ingredient Quality and Safety

Ease of Use and Application

1
Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub
Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub
Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub
Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub
Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub

Palmer's for Pets Paw Pad & Nose Balm with Cocoa Butter, 3.5-fl oz tub

Rated 4.6 out of 5 stars
1,035
$6.38 Chewy Price
($1.83/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.4/5
Great

Skin and Coat Health

4.4/5
Great

Ingredient Quality and Safety

4.2/5
Great

Ease of Use and Application

4.6/5
Excellent

Is this dog hot spot spray & cream right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Paraffinum Liquidum (Mineral Oil), Cera Microcristallina (Microcrystalline Wax), Butyrospermum Parkii (Shea) Butter, Dimethicone, Theobroma Cacao (Cocoa) Seed Butter

Health Feature

Paw Care
2
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar
Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar

Pet MD Paw Balm 3-in-1 Nose/Snout & Elbow Moisturizer & Paw Protectors Paw Wax with Shea Butter, Coconut Oil, & Beeswax for Dogs, 2-fl oz jar

Rated 4.6 out of 5 stars
952
$15.49 Chewy Price
($7.75/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.5/5
Great

Skin and Coat Health

4.3/5
Great

Ingredient Quality and Safety

4.3/5
Great

Ease of Use and Application

4.5/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Shea Butter, Olive Oil, Almond Oil, Coconut Oil, Beeswax

Health Feature

Skin & Coat Health
3
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray

Veterinary Formula Clinical Care Antiseptic & Antifungal Medicated Spray, 8-fl oz spray

Rated 4.5 out of 5 stars
1,492
$8.78 Chewy Price
($1.10/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.4/5
Great

Skin and Coat Health

4.3/5
Great

Ingredient Quality and Safety

4.3/5
Great

Ease of Use and Application

4.4/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds, Extra Small Breeds...

Lifestage

All Lifestages, Adult

Top Ingredients

Purified Water, Chlorhexidine Gluconate, Glycerin USP, Chitosan Succinamide (and) Hydrolyzed Keratin (and) Polyquaternium-10, Polysorbate-20

Health Feature

Itch & Redness Remedy, Skin & Coat Health
4
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle

Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle

Rated 4.6 out of 5 stars
481
$8.00 Chewy Price
($1.00/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.4/5
Great

Skin and Coat Health

4.3/5
Great

Ingredient Quality and Safety

4.3/5
Great

Ease of Use and Application

4.4/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Chlorhexidine Gluconate, Phospholipid Complex, PCMX, SDA 40, Polyoxyethylene Sorbitan Monolaurate

Health Feature

Itch & Redness Remedy, Skin & Coat Health
5
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle
Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle

Chew + Heal Advanced Chlorhexidine Medicated Wound Care Spray for Dogs, 8-fl oz bottle

Rated 4.8 out of 5 stars
46
$19.99 Chewy Price
($2.50/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.6/5
Excellent

Skin and Coat Health

4.6/5
Excellent

Ingredient Quality and Safety

4.5/5
Great

Ease of Use and Application

4.7/5
Excellent

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Top Ingredients

Inactive Ingredients: Water, Glycerine, Propylene Glycol, Polysorbate 20, Lactic Acid

Health Feature

Anti-Fungal / Anti-Bacterial, First Aid
6
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle

Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle

Rated 4.5 out of 5 stars
531
$16.84 Chewy Price
($8.42/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.4/5
Great

Skin and Coat Health

4.2/5
Great

Ingredient Quality and Safety

4.4/5
Great

Ease of Use and Application

4.4/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrocortisone 1.0%., Inactive Ingredients: Aloe Vera, Benzoic Acid, Benzyl Alcohol, Dipropylene Glycol

Health Feature

Itch & Redness Remedy, Skin & Coat Health
7
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle
Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle

Vetnique Labs Dermabliss Anti-Itch & Allergy Relief Hydrocortisone Fragrance-Free Dog & Cat Skin Spray, 4-fl oz bottle

Rated 4.3 out of 5 stars
969
$18.99 Chewy Price
($4.75/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.0/5
Great

Skin and Coat Health

4.0/5
Great

Ingredient Quality and Safety

3.9/5
Good

Ease of Use and Application

4.0/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: Hydrocortisone 1%, Pramoxine Hydrochloride 0.5%, Inactive: Propylene Glycol, Water, SD Alcohol 40B

Health Feature

Allergy Relief
8
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle
DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle

DermAllay Oatmeal Spray Conditioner for Dogs, Cats & Horses, 12-fl oz bottle

Rated 4.6 out of 5 stars
123
$25.68 Chewy Price
($2.14/oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.6/5
Excellent

Skin and Coat Health

4.5/5
Great

Ingredient Quality and Safety

4.4/5
Great

Ease of Use and Application

4.6/5
Excellent

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Top Ingredients

Contains: Water, Glycerine, Silicone Emulsion, Stearamidopropyl Dimethylamine Lactate, Polysorbate 20

Health Feature

Skin & Coat Health
9
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle

Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle

Rated 4.2 out of 5 stars
799
$22.56 Chewy Price
($2.82/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.3/5
Great

Skin and Coat Health

4.3/5
Great

Ingredient Quality and Safety

4.3/5
Great

Ease of Use and Application

4.3/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

Small Breeds, All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Sabilized Hydronium (H9 O4) & Purified Water

Health Feature

First Aid, Anti-Fungal / Anti-Bacterial
10
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle
Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle

Smiling Paws Pets Antibacterial & Antifungal Medicated Dog & Cat Spray, 8-fl oz bottle

Rated 4.5 out of 5 stars
243
$16.97 Chewy Price
($2.13/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness

4.2/5
Great

Skin and Coat Health

4.1/5
Great

Ingredient Quality and Safety

4.1/5
Great

Ease of Use and Application

4.4/5
Great

Is this dog hot spot spray & cream right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Chrlorhexidine Gluconate, Ketoconazole, Water, Glycerine, Propylene Glycol

Health Feature

Anti-Fungal / Anti-Bacterial