10 Best Hot Spot Treatments for Cats 2025: According to Reviews | Chewy

The 10 Best Hot Spot Treatments for Cats

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How we created this hot spot treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best hot spot treatments for cat.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best hot spot treatments for cats.

Key hot spot treatment considerations

Ease of Use

Effectiveness

Ingredients

Long-Term Results

1
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray

Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray, 8-fl oz spray

Rated 4.4 out of 5 stars
1,715
$8.49Chewy Price
($1.07/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Long-Term Results

4.3/5
Great

Is this hot spot treatment right for my pet?

Breed Size

Small Breeds, Extra Small Breeds, Medium Breeds, Giant Breeds...

Lifestage

All Lifestages, Adult

Top Ingredients

Purified Water, Glycerin, Polysorbate-20, Lidocaine HCI, Allantoin

Health Feature

Itch & Redness Remedy, Skin & Coat Health
2
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle
Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle

Zesty Paws Wild Alaskan Omega-3 Salmon Oil Liquid Skin & Coat Supplement for Dogs & Cats, 32-fl oz bottle

Rated 4.3 out of 5 stars
3,869
$36.97Chewy Price
($1.16/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Long-Term Results

4.0/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Pollock Oil, Salmon Oil, Mixed Tocopherols (a preservative)

Food Flavor

Salmon, Seafood & Fish
3
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle
Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle

Davis Chlorhexidine Dog & Cat Spray, 8-fl oz bottle

Rated 4.6 out of 5 stars
328
$9.64Chewy Price
($1.21/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.5/5
Great

Long-Term Results

4.4/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Chlorhexidine Gluconate, Phospholipid Complex, PCMX, SDA 40, Polyoxyethylene Sorbitan Monolaurate

Health Feature

Itch & Redness Remedy, Skin & Coat Health
4
Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle
Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle
Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle
Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle
Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle

Iceland Pure Pet Products Unscented Pharmaceutical Grade Sardine & Anchovy Oil Liquid Dog & Cat Supplement, 33-fl oz bottle

Rated 4.5 out of 5 stars
291
$56.90Chewy Price
($1.73/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.7/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.7/5
Excellent

Long-Term Results

4.7/5
Excellent

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

60% Sardine, 40% Anchovy, Mixed Tocopherols (preservative)

Special Diet

Gluten Free, Grain-Free, Human-Grade, Non-GMO...
5
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle
Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle

Vetnique Labs Dermabliss Medicated Hot Spot Antiseptic Chlorhexidine Dog & Cat Skin Spray, 8-oz bottle

Rated 4.5 out of 5 stars
165
$19.99Chewy Price
($2.50/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.7/5
Excellent

Long-Term Results

4.3/5
Great

Is this hot spot treatment right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Chlorhexidine Gluconate, Ketconazole, Water, Glycerin, Propylene Glycol

Health Feature

Itch & Redness Remedy
6
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle
Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle

Zymox Topical Spray with Hydrocortisone 1.0% for Dogs & Cats, 2-fl oz bottle

Rated 4.5 out of 5 stars
460
$16.99Chewy Price
($8.50/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Long-Term Results

4.3/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrocortisone 1.0%., Inactive Ingredients: Aloe Vera, Benzoic Acid, Benzyl Alcohol, Dipropylene Glycol

Health Feature

Itch & Redness Remedy, Skin & Coat Health
7
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle
Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle

Pet Honesty Wild Caught Omega-3 Fish Oil Liquid Skin & Coat Health Supplement for Dogs & Cats, 32-fl oz bottle

Rated 4.3 out of 5 stars
993
$36.99Chewy Price
($1.16/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.1/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Long-Term Results

4.2/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Fat, Moisture, Total Omega-3 Fatty Acids, EPA, DHA

Special Diet

No Corn No Wheat No Soy, Non-GMO
8
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle
Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle

Banixx Pet Care+ Wound Care & Anti-Itch Spray for Dogs, Cats & Small Pets, 8-fl oz bottle

Rated 4.2 out of 5 stars
745
$16.99Chewy Price
($2.13/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Long-Term Results

4.2/5
Great

Is this hot spot treatment right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Sabilized Hydronium (H9 O4) & Purified Water

Health Feature

First Aid, Anti-Fungal / Anti-Bacterial
9
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle
Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle

Wonder Paws Fish Oil Skin, Joint, Immune & Heart Health Liquid Supplement for Dogs, 16-fl oz bottle

Rated 4.5 out of 5 stars
201
$21.95Chewy Price
($1.38/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Long-Term Results

4.2/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Salmon Oil, Cod Liver Oil, Krill Oil, Astaxanthin Oil

Special Diet

Human-Grade, Natural
10
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count
Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count

Bark&Spark Allergy Relief & Itch Relief with Omega 3 Skin & Coat with Salmon Oil Chew Supplement for Dogs, 180 count

Rated 4.4 out of 5 stars
164
$24.99Chewy Price
($0.14/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.4/5
Great

Long-Term Results

4.3/5
Great

Is this hot spot treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Inactive Ingredients: Potato, Flaxseed, Glycerin, Brewers Dried Yeast, Lecithin

Special Diet

Non-GMO, Chicken-Free