Best OTC Diarrhea Treatments for Dogs 2026: According to Reviews | Chewy

Best OTC Diarrhea Treatments For Dogs

Digestive issues can happen unexpectedly, and having the right support on hand can make a stressful moment easier. The best OTC diarrhea treatments for dogs provide relief while being simple to use. As always, if your dog is lethargic, vomiting repeatedly, has significant blood in the stool, or if diarrhea persists beyond 48 hours, veterinary care is recommended.

Our Top Picks

How we created this otc diarrhea treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best otc diarrhea treatments for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best otc diarrhea treatments for dogs.

Key otc diarrhea treatment considerations

Ease of Use

Effectiveness

Ingredients

Speed of Relief

1
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Rated 4.6 out of 5 stars
2,345
$26.98 Chewy Price
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Ml: Kaolin 0.6 G, Pectin 0.025 G, Direct-Fed Microbials 0.2 Billion Cfu (Enterococcus Faecium) Kaolin, Soy Oil, Pectin

Health Feature

Digestive Health
2
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Rated 4.5 out of 5 stars
601
$13.96 Chewy Price
($2.33/ea)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Speed of Relief

4.3/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Apple Pomace, Brewer’s Yeast, Citrus Pulp, Glucose, Pectin

Food Flavor

Chicken
3
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Rated 4.6 out of 5 stars
436
$125.85 Chewy Price
($0.26/ea)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Activated Attapulgite with Roasted Powdered Carob Pulp, Citrus Pectin, Magnesium Trisilicate, Colloidal Aluminum Silicate (Hydrated) with Artificial Color and Base

Health Feature

Digestive Health
4
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz tube
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz tube
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz tube

Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz tube

Rated 4.6 out of 5 stars
483
$19.57 Chewy Price
($6.53/oz)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Liquid Petrolatum, Cod Liver Oil, Soybean Oil, Peptonized Iron

Health Feature

Hairball Control, Digestive Health
5
Van Beek Natural Science Diagel for Digestive Issues for Dogs, 5-ml
Van Beek Natural Science Diagel for Digestive Issues for Dogs, 5-ml

Van Beek Natural Science Diagel for Digestive Issues for Dogs, 5-ml

Rated 4.7 out of 5 stars
334
$29.29 Chewy Price
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Carvacrol., Inactive Ingredients: Carob, Chamomile Oil, Cinnamon Oil, Clove Oil

Special Diet

Natural
6
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Rated 4.5 out of 5 stars
270
$15.97 Chewy Price
($2.00/fl oz)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Pectin And Kaolin, Inactive Ingredients: Water, Glycerin, Sorbic Acid, Xanthan Gum

Health Feature

Digestive Health
7
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

Rated 4.5 out of 5 stars
468
$19.49 Chewy Price
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Aconitum Napellus, 200c, Aloe 6c, 30c, 200c

Special Diet

Natural
8
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count

Rated 4.6 out of 5 stars
1,701
$29.99 Chewy Price
($0.50/ea)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.3/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Tablet: Kaolin 1.00 G, Pectin 50 MG Direct-Fed Microbials (Enterococcus Faecium) 0.6 Billion Cfu , Inactive Ingredients: Artificial Beef Flavor, Brewers Yeast, Dicalcium Phosphate

Health Feature

Digestive Health
9
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

Rated 4.2 out of 5 stars
560
$6.48 Chewy Price
($1.62/fl oz)
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.2/5
Great

Speed of Relief

4.2/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per Teaspoon: Kaolin 8.0%, Inactive Ingredients: Calcium Amino Acid Chelate, Glycerin, Lactic Acid, Magnesium Amino Acid Chelate

Health Feature

Digestive Health
10
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc

VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc

Rated 4.4 out of 5 stars
215
$42.22 Chewy Price
Promo, New Customers Only: Spend $49+, get $15 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: (Per 10 Cc Serving) Pantothenic Acid 10.5 mg, Pyridoxine HCl (Vitamin B6) 2.5 mg, Riboflavin (Vitamin B2) 1.0 mg, Mixed Lactic Acid Bacteria 1.3 X 10^7 Cfu Saccharomyces Cerevisiae 3.4 X 10^6 Cfu Bacillus Subtilis 3.8 X 10^5 Cfu Aspergillus Oryzae 1.3 X 10^5 Cfu., Inactive Ingredients: Carrageenan

Special Diet

Human-Grade