10 Best OTC Diarrhea Treatments for Dogs 2025: According to Reviews | Chewy

The 10 Best OTC Diarrhea Treatments for Dogs

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How we created this otc diarrhea treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best otc diarrhea treatments for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best otc diarrhea treatments for dogs.

Key otc diarrhea treatment considerations

Ease of Use

Effectiveness

Ingredients

Speed of Relief

1
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Rated 4.5 out of 5 stars
1,328
$22.49Chewy Price
Promo, Save 40% on your first Autoship

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Ml: Kaolin 0.6 G, Pectin 0.025 G, Direct-Fed Microbials 0.2 Billion Cfu (Enterococcus Faecium) Kaolin, Soy Oil, Pectin

Health Feature

Digestive Health
2
PRN Pharmacal Pet-Ema Medication for Constipation for Dogs & Cats, 12-ml bottle

PRN Pharmacal Pet-Ema Medication for Constipation for Dogs & Cats, 12-ml bottle

Rated 4.6 out of 5 stars
268
$5.82Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.8/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.6/5
Excellent

Speed of Relief

4.7/5
Excellent

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Dioctyl Sodium Sulfosuccinate, Glycerin, and Sorbic acid

Health Feature

Digestive Health
3
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Rated 4.5 out of 5 stars
284
$13.97Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.3/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Apple Pomace, Brewer’s Yeast, Citrus Pulp, Glucose, Pectin

Food Flavor

Chicken
4
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz bottle
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz bottle
Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz bottle

Lax-Aire Medication for Digestive Issues for Cats & Dogs, 3-oz bottle

Rated 4.5 out of 5 stars
264
$17.66Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Liquid Petrolatum, Cod Liver Oil, Soybean Oil, Peptonized Iron

Health Feature

Hairball Control, Digestive Health
5
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Rated 4.5 out of 5 stars
226
$115.35Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Activated Attapulgite with Roasted Powdered Carob Pulp, Citrus Pectin, Magnesium Trisilicate, Colloidal Aluminum Silicate (Hydrated) with Artificial Color and Base

Health Feature

Digestive Health
6
Van Beek Natural Science Diagel Medication for Digestive Issues for Dogs, 1-ml

Van Beek Natural Science Diagel Medication for Digestive Issues for Dogs, 1-ml

Rated 4.7 out of 5 stars
176
$22.19Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Carvacrol., Inactive Ingredients: Carob, Chamomile Oil, Cinnamon Oil, Clove Oil

Health Feature

Digestive Health
7
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 250 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 250 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 250 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 250 count

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 250 count

Rated 4.6 out of 5 stars
810
$69.99Chewy Price
Promo, Save 40% on your first Autoship

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Tablet: Kaolin 1.00 G, Pectin 50 MG Direct-Fed Microbials (Enterococcus Faecium) 0.6 Billion Cfu , Inactive Ingredients: Artificial Beef Flavor, Brewers Yeast, Dicalcium Phosphate

Health Feature

Digestive Health
8
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Rated 4.5 out of 5 stars
150
$15.97Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.2/5
Great

Speed of Relief

4.6/5
Excellent

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Pectin And Kaolin, Inactive Ingredients: Water, Glycerin, Sorbic Acid, Xanthan Gum

Health Feature

Digestive Health
9
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

Rated 4.2 out of 5 stars
325
$6.48Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Ease of Use

4.3/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Speed of Relief

4.0/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per Teaspoon: Kaolin 8.0%, Inactive Ingredients: Calcium Amino Acid Chelate, Glycerin, Lactic Acid, Magnesium Amino Acid Chelate

Health Feature

Digestive Health
10
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

Rated 4.5 out of 5 stars
331
$17.99Chewy Price
Promo, Save 40% on your first Autoship

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.3/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Aconitum Napellus, 200c, Aloe 6c, 30c, 200c

Packaging Type

Bulk