Best OTC Diarrhea Treatments for Dogs 2026: According to Reviews | Chewy

Best OTC Diarrhea Treatments For Dogs

Digestive issues can happen unexpectedly, and having the right support on hand can make a stressful moment easier. The best OTC diarrhea treatments for dogs provide relief while being simple to use. As always, if your dog is lethargic, vomiting repeatedly, has significant blood in the stool, or if diarrhea persists beyond 48 hours, veterinary care is recommended.

Our Top Picks

How we created this otc diarrhea treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best otc diarrhea treatments for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best otc diarrhea treatments for dogs.

Key otc diarrhea treatment considerations

Ease of Use

Effectiveness

Ingredients

Speed of Relief

1
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 30-cc syringe

Rated 4.6 out of 5 stars
2,450
$26.99 Chewy Price
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Ml: Kaolin 0.6 G, Pectin 0.025 G, Direct-Fed Microbials 0.2 Billion Cfu (Enterococcus Faecium) Kaolin, Soy Oil, Pectin

Health Feature

Digestive Health
2
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets
Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Endosorb Medication for Digestive Issues & Diarrhea for Dogs & Cats, 1.5-g, 500 tablets

Rated 4.6 out of 5 stars
455
$125.85 Chewy Price
($0.26/ea)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Activated Attapulgite with Roasted Powdered Carob Pulp, Citrus Pectin, Magnesium Trisilicate, Colloidal Aluminum Silicate (Hydrated) with Artificial Color and Base

Health Feature

Digestive Health
3
Van Beek Natural Science Diagel for Digestive Issues for Dogs, 5-ml

Van Beek Natural Science Diagel for Digestive Issues for Dogs, 5-ml

Rated 4.7 out of 5 stars
352
$28.00 Chewy Price
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Carvacrol., Inactive Ingredients: Carob, Chamomile Oil, Cinnamon Oil, Clove Oil

Special Diet

Natural
4
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count
Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Vetality Stop the Runs Anti Diarrhea Medication for Dogs, 6 count

Rated 4.5 out of 5 stars
644
$13.96 Chewy Price
($2.33/ea)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.2/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Speed of Relief

4.2/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Apple Pomace, Brewer’s Yeast, Citrus Pulp, Glucose, Pectin

Food Flavor

Chicken
5
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops
HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

HomeoPet Digestive Upsets Homeopathic Medicine for Digestive Issues for Birds, Cats, Dogs & Small Pets, 450 drops

Rated 4.5 out of 5 stars
481
$19.49 Chewy Price
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Aconitum Napellus, 200c, Aloe 6c, 30c, 200c

Special Diet

Natural
6
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle
Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Vets Preferred Advanced Medication for Diarrhea for Dogs, 8-fl oz bottle

Rated 4.5 out of 5 stars
280
$15.97 Chewy Price
($2.00/fl oz)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.5/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Pectin And Kaolin, Inactive Ingredients: Water, Glycerin, Sorbic Acid, Xanthan Gum

Health Feature

Digestive Health
7
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count
Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count

Vetoquinol Pro-Pectalin Diarrhea Supplement for Dogs & Cats, 60 count

Rated 4.6 out of 5 stars
1,811
$29.99 Chewy Price
($0.50/ea)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Speed of Relief

4.3/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Per Tablet: Kaolin 1.00 G, Pectin 50 MG Direct-Fed Microbials (Enterococcus Faecium) 0.6 Billion Cfu , Inactive Ingredients: Artificial Beef Flavor, Brewers Yeast, Dicalcium Phosphate

Health Feature

Digestive Health
8
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle
PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

PetAg Pet Pectillin Anti-Diarrheal Medication for Dogs & Cats, 4-fl oz bottle

Rated 4.2 out of 5 stars
582
$6.48 Chewy Price
($1.62/fl oz)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.2/5
Great

Speed of Relief

4.2/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per Teaspoon: Kaolin 8.0%, Inactive Ingredients: Calcium Amino Acid Chelate, Glycerin, Lactic Acid, Magnesium Amino Acid Chelate

Health Feature

Digestive Health
9
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle
Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle

Nutri-Vet Anti-Diarrhea Liquid Medication for Dogs, 4-fl oz bottle

Rated 4.4 out of 5 stars
268
$9.79 Chewy Price
($2.45/fl oz)
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per tsp (5 ml): Koalin - 8% Pectin - 0.8%, Inactive Ingredients: Water, Glycerin, Sorbitol, Potassium Sorbate

Health Feature

Digestive Health
10
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc
VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc

VetriScience Fast Balance G.I. Paste Medication for Digestive Issues for Cats & Dogs, 60-cc

Rated 4.4 out of 5 stars
224
$42.22 Chewy Price
Promo, New Customers Only: Spend $49+, get $25 eGift Card

Our ratings

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Speed of Relief

4.4/5
Great

Is this otc diarrhea treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: (Per 10 Cc Serving) Pantothenic Acid 10.5 mg, Pyridoxine HCl (Vitamin B6) 2.5 mg, Riboflavin (Vitamin B2) 1.0 mg, Mixed Lactic Acid Bacteria 1.3 X 10^7 Cfu Saccharomyces Cerevisiae 3.4 X 10^6 Cfu Bacillus Subtilis 3.8 X 10^5 Cfu Aspergillus Oryzae 1.3 X 10^5 Cfu., Inactive Ingredients: Carrageenan

Special Diet

Human-Grade

Frequently Asked Questions about Otc Diarrhea Treatments for Dogs

What kinds of over-the-counter diarrhea treatments are available for dogs, and how do they work?

Common options include stool-firming adsorbents such as kaolin-pectin or clay-based formulas, probiotic microbiome support that adds direct-fed microbials, and gentle herbal or homeopathic drops. These come as powders, liquids, pastes, chews, or tablets, and they are designed to firm stools and soothe the GI tract for short-term relief.

When should I manage my dog's diarrhea at home with OTC products versus seeing a vet?

Mild, sudden diarrhea in an otherwise bright dog can often be supported at home with OTC products made for dogs and used as directed. Seek veterinary care if your dog is straining, lethargic, vomiting repeatedly, has blood in the stool, or if diarrhea lasts beyond 48 hours.