Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)

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About This Item

Details

  • This topical treatment is formulated just for cats.
  • The fast-acting formula helps kill and prevent fleas within 30 minutes of application.
  • It’s designed to kill up to 98–100% of fleas within 12 hours.
  • Cheristin can help put a quick stop to excessive meowing and scratching.
  • It also comes with a ready-to-use applicator, so it’s easy to apply.

Ingredients

Instructions

FAQ

Learn More About Cheristin From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Questions & Answers

27 Customer Questions


Does this dose matter for the weight of my cats? They are 17 and 20 pounds each and the Advantage XD has same type ingredients but has size options and larger size lasts two months compared to the 6 weeks. Is the weight difference going to affect it working properly?


It's been 3 weeks and my cat still has a bunch of fleas on his ears and nose. Should I apply another treatment and hope it will eventually work or assume it's not going to work for him and try something else?

Answer by ChewyAug 02, 2018
If you see fleas on your cat within a month after your pet receives flea treatment with Cheristin for cats, it is most likely these are new fleas that have very recently emerged from pupae and jumped onto the cat. These new fleas will be killed quickly before they can produce eggs that contaminate the environment.Consistent monthly application of Cheristin for cats should be maintained to provide continued protection for your cat against these fleas.

Is this the same strength that I can buy at the vet's office?

Answer by ChewyJun 27, 2018
This treatment is equivalent to treatments sold at a veterinarian office.

How do I know if the Cheristin flea medication is made in USA and bought from a reputable source?

Answer by ChewyDec 06, 2019
Cheristin for Cats is manufactured in Clinton, Indiana. Chewy sources all our products from manufacturer approved distributors or directly from the manufacturers. Chewy takes pride in ensuring that our furry friends’ well being is always our top priority. We have worked hard to partner with all of the manufactures to deliver 100% authentic products.

4.5
Rated 4.5 out of 5 stars
3440 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

87% Positive

Effectiveness

87% Positive

Ingredients

85% Positive

Long-Term Benefits

87% Positive

1854 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Barbara on Jan 7, 2026

Reliable without RX.

What was great is that is actually worked. I had to find a different flea medicine because I had been using and over paying for revolution, and had to have a prescription

What was great is that is actually worked. I had to find a different flea medicine because I had been using and over paying for revolution, and had to have a prescription for. One more great thing is you can buy it without a prescription. No more waiting for the vet to send over RX. This medicine is an oil based not alcohol so it doesn’t sting like the alcohol based meds. I will be using this one for some time.


Rated 5 out of 5 stars
By Kay on Dec 24, 2025

Great stuff, but you must isolate cat 24 hrs.

Great stuff -- stops a flea infestation dead in its tracks immediately. However, in a multi cat household, you need to isolate treated cats for 24 hours to avoid

Great stuff -- stops a flea infestation dead in its tracks immediately. However, in a multi cat household, you need to isolate treated cats for 24 hours to avoid other cats grooming the treated cat. Treatment is the standard "top spot" method of applying where the treated cat can't lick. Treatment does not need to be dosed by weight. You will also want to treat the house with an IGR like methoprene or pyriproxifen, just to get the new fleas hatching out after the cat is treated.


Rated 5 out of 5 stars
By Angelica on Dec 27, 2025

GET IT !!!

I used it on my 3 cats it worked really good for 3 weeks but then I seen there was fleas coming back so I gave them another dose and so far I haven't seen any. It

I used it on my 3 cats it worked really good for 3 weeks but then I seen there was fleas coming back so I gave them another dose and so far I haven't seen any. It has been around 2 months since the last one I say give it a few tries before giving up on it. The products starts working pretty fast and is good. But also keep in mind clean everything as well as wash in case any eggs are left behind. This product worked wonderful and i do recommend it


Rated 2 out of 5 stars
By Hilary on Jan 24, 2026

Unfortunately did not work

This is the second flea med that I've tried for my cats. (First was nexgard from the vet) neither that nor this Cheristin worked. I don't know what to do now for

This is the second flea med that I've tried for my cats. (First was nexgard from the vet) neither that nor this Cheristin worked. I don't know what to do now for my cats to get rid of the fleas. This is not Chewey's fault, they had great, quick delivery service. Thank you Chewy.


Rated 5 out of 5 stars
By Cathy on Dec 2, 2025

Good price for very effective product

One size fits all-none of that buying 3 boxes because all your cats are in different weight ranges. Vials open easily with just a twist. I flea combed all 11 cats

One size fits all-none of that buying 3 boxes because all your cats are in different weight ranges. Vials open easily with just a twist. I flea combed all 11 cats 12 hours or so after applying it and didn't find but 2 fleas on all 11 kitties. They were gone. It's been 2 weeks now and still not one flea. None of the 11 cats had any reaction at all to the Cheristin, which is great. What I don't like is that it stayed wet for over a day--some of the dose wicks up the hair at the application site, this cannot be avoiding with these topical products, and after 24 hours, I gently blotted the spot with a Kleenex, just pressed down on the wet spot, no rubbing. Next day, the fur was dry. This issue was not unique to Cheristin, every topical I've ever used caused this. Cheristin is half the price of my old product and works very well, maybe better than it did. I will continue to choose it.


Rated 5 out of 5 stars
By LARS on Jan 24, 2026

Works

With all the different spot flea drops and other types of flea killers...... It has been rough watching pets scratch and having to use flea comb. No other flea meds

With all the different spot flea drops and other types of flea killers...... It has been rough watching pets scratch and having to use flea comb. No other flea meds works. Cheristan seems to be an under advertised winning solution.


Rated 1 out of 5 stars
By peter on Jan 21, 2026

Hard to open

The cap was on the tube so tight that we spun it and spun it and spun it exactly like the direction said, and it never opened. We had to get scissors and cut through

The cap was on the tube so tight that we spun it and spun it and spun it exactly like the direction said, and it never opened. We had to get scissors and cut through the cap in order to use the product. Very, Very frustrating.


Rated 5 out of 5 stars
By Emily on Jan 12, 2026

Works so fast!

I’ve been using this for years. My girls were ferals when they first became mine and they were full of fleas. I used this on them and within the next week I physically

I’ve been using this for years. My girls were ferals when they first became mine and they were full of fleas. I used this on them and within the next week I physically saw the dead fleas flaking off their chins! I have been using it ever since.


Rated 4 out of 5 stars
By Tabetha on Jan 11, 2026

Good

It was good as long as it is in a spot where they definitely couldn’t lick. Milo was a little to low and licked it and it made him pant bad and he couldn’t sit still

It was good as long as it is in a spot where they definitely couldn’t lick. Milo was a little to low and licked it and it made him pant bad and he couldn’t sit still. Like it made his heart race, so I gave him a bath and he calmed down.


Rated 4 out of 5 stars
By Teresa on Dec 28, 2025

Effective for Our Needs

We have an indoor cat that goes out on a screened in porch so we have selected to use a non-prescription, less expensive topical solution in the event kitty comes

We have an indoor cat that goes out on a screened in porch so we have selected to use a non-prescription, less expensive topical solution in the event kitty comes into contact with fleas. The caps are sometimes not working and we end up having to cut the cap and lose a bit of product.