Revolution Plus Topical Solution for Cats 5.6-11 lbs (Orange Box), 1 Dose (1-mos. supply)

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About This Item

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Help protect your four-legged friend from pesky critters with this 6-in-1 broad spectrum monthly Topical Solution for Cats by Revolution Plus. Simply apply the quick-drying, small-volume prescription to help: kill fleas before they lay eggs, kill ticks for a full month, prevent heartworm disease and treat and control roundworms, hookworms and ear mites. This topical medication is suitable for cats and kittens eight weeks of age or older, weighing between 5.6 and 11 pounds.We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer. One and three count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag. Please note, due to a manufacturer prompted packaging change, your medication may arrive in new packaging.

Ingredients

Instructions

FAQ

Learn More About Revolution Plus From Our Team of Experts

Veterinarians’ #1 Trusted Choice in Feline Parasite Protection[1]

The Revolution (selamectin) brand has over 25 years of proven protection. Revolution Plus (selamectin and sarolaner topical solution) is the most prescribed medicine for feline parasite defense. It’s available as an easy-to-administer monthly topical solution.

Pest Protection for Indoor & Outdoor Cats

No matter their lifestyle, Revolution Plus protects your cat from the most common parasites:

  • Fleas
  • Tapeworms*
  • 4 Types of Ticks
  • Ear Mites
  • Roundworms
  • Hookworms
  • Heartworm Disease

*Prevents flea tapeworm (Dipylidium caninum) by killing fleas.

Because Every Cat Needs Parasite Protection

It's approved for cats and kittens as young as 8 weeks old, weighing 2.8 lbs or more, and is the only prescription combination preventative that protects against 4 types of ticks.

Protect Your Cat & Earn Rewards From Zoetis

Your 6-or 12-count Revolution Plus purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Revolution Plus

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Revolution Plus contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions, such as tremors, ataxia, and seizures in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See full Prescribing Information at RevolutionPlusPI.com.

References:

  1. ZMR: Kynetec PetTrak Veterinary Channel Review. Q4 2024. Data on file. Zoetis Inc.

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4.8
Rated 4.8 out of 5 stars
5481 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

92% Positive

Effectiveness

92% Positive

Ingredients

88% Positive

Long-Term Benefits

91% Positive

1814 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Catmom on Dec 31, 2025

High quality

I saved these lives for a reason, to provide love/care/attention as they deserve, nurse them back to health and healing while adding a significant amount of time

I saved these lives for a reason, to provide love/care/attention as they deserve, nurse them back to health and healing while adding a significant amount of time to their little lives. Therefore....(even though they are inside cats, yet they do only go outside while monitored the whole time since we do not have a fence all the way around with the beautiful nature and waterway behind us that includes an eagle, coyotes, and whatever other predators..).. I prefer them to have the best, most efficient, reliable, high quality, safe flea or pest control medication that covers a vast majority of pests by killing and/or preventing more pests than most of the others. This includes more types of ticks, ear mites, and I believe one other thing.. those pests are not only a nuisance, bothersome and irritating, They can also make them very ill especially since one of my babies has always been a little sickly..That is also not the quality of life I am trying to provide for them.

Rated 5 out of 5 stars
By lynn on Dec 29, 2025

Works well

The vet recommended this. I noticed “flea dirt” on a white towel. I never had problems with fleas before due to always keeping my kitties in the house but this

The vet recommended this. I noticed “flea dirt” on a white towel. I never had problems with fleas before due to always keeping my kitties in the house but this year was different. But seems to have worked. I keep the cats separated until the treatment has fully dried to avoid stomach upset. Chew made ordering the medicine really easy and it come quickly. Thanks chewy for the great service.

Rated 5 out of 5 stars
By Christine on Nov 26, 2025

It works!

I was using Frontline Plus on my 4 cats for 3 months to get rid of fleas that I must have carried in on my shoe this fall (all my cats are strictly indoor). Frontline

I was using Frontline Plus on my 4 cats for 3 months to get rid of fleas that I must have carried in on my shoe this fall (all my cats are strictly indoor). Frontline was recommended by a friend who works at a vet as being a less expensive and quickly available option compared to prescription flea treatments. I'm sure it works fine for some, like my mom for her outdoor cats (she swears by it). But I read fleas can develop a resistance to it. In my case, they clearly did. I ended up with a mild-moderate infestation that just seemed to be progressively getting worse. My Vet recommended Revolution Plus. What a HUGE difference in just the first few weeks. With carpet treatment, loads of vacuuming and laundry, mattress encasements on every couch, cushion, pillow and mattress, were finally gaining our normal home back! They aren't 100% gone, but it hasn't even been a full month on Revolution and it's significantly better. The vet did warn it could take 3-4 months on this new med to fully eradicate them. But in the meantime, it's really nice for me and my babies not to be constantly scratching. Fingers crossed this continues to work as well as it has these past few weeks!!

Rated 5 out of 5 stars
By diana on Jan 15, 2026

Easy to use on my feral cat.

In just a day I saw great changes happening he wasn’t scratching his ears as much and seem calmer bc the medication was getting rid of the ear mites and whatever

In just a day I saw great changes happening he wasn’t scratching his ears as much and seem calmer bc the medication was getting rid of the ear mites and whatever else was bothering him. In 2 weeks his ears were clean inside and fur shiny and healthy. A whole new and happy cat.

Rated 5 out of 5 stars
By Dianne on Jan 18, 2026

Never a flea with this product

Recommended by my vet because my cat couldn’t tolerate newer stronger ones. I love this product both because he tolerates it and because even living in FL (tied

Recommended by my vet because my cat couldn’t tolerate newer stronger ones. I love this product both because he tolerates it and because even living in FL (tied with Louisiana for worst flea state) he never has a flea, and I comb him every day.

Rated 5 out of 5 stars
By Danielle on Dec 30, 2025

Simple compete coverage.

We have used this product for years - simple to apply like all topicals. But its the comprehensive coverage INCLUDING heartworm that is worth every penny. If you

We have used this product for years - simple to apply like all topicals. But its the comprehensive coverage INCLUDING heartworm that is worth every penny. If you don't protect against heartworm (even inside kitties can be affected!) I strongly recommend it.

Rated 5 out of 5 stars
By Jane on Dec 4, 2025

Great coupon for much needed item

I've had my 18 year-old cat on this medication for fleas, ticks, etc. for many years. I shop around because it is a must have. Chewy was offering a $20 coupon

I've had my 18 year-old cat on this medication for fleas, ticks, etc. for many years. I shop around because it is a must have. Chewy was offering a $20 coupon and I went for it. They contact my vet and then fill the prescription. Chewy has other great products for dogs too. Try it sometime soon.

Rated 5 out of 5 stars
By Rick on Jan 5, 2026

This definitely works.

We are on our second round of Revolution Plus at the advice of our vet and couldn't be happier with the results. It's so nice to get the flea collars off our cats

We are on our second round of Revolution Plus at the advice of our vet and couldn't be happier with the results. It's so nice to get the flea collars off our cats and still know that they are well protected. Thanks!

Rated 5 out of 5 stars
By Roseann on Dec 26, 2025

Easy and fast prescription process.

The pharmacist took the order and expedited it for me. After 2 doses, my cat is no longer scratching and has no sign of fleas. However, I've been told that it

The pharmacist took the order and expedited it for me. After 2 doses, my cat is no longer scratching and has no sign of fleas. However, I've been told that it takes 3 monthly doses to complete the cycle. It works!

Rated 5 out of 5 stars
By Cynthia on Dec 29, 2025

No flea or worms

I easily get eat up by fleas and my house is pest free and my cat is in and out all the time. No itching or anything. He wouldn't be sleeping on my bed if we had

I easily get eat up by fleas and my house is pest free and my cat is in and out all the time. No itching or anything. He wouldn't be sleeping on my bed if we had a flea issue.