7 Best Calming Pills for Dogs 2025: According to Reviews | Chewy

The 7 Best Calming Pills for Dogs

Jump to the list

How we created this calming pill list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best calming pills for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best calming pills for dogs.

Key calming pill considerations

Dosage and Administration

Effectiveness

Ingredients

Long-term Effects

1
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

Rated 4.1 out of 5 stars
712
$35.99Chewy Price
($1.20/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Long-term Effects

4.1/5
Great

Is this calming pill right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin

Health Feature

Calming
2
Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count
Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count
Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count
Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count

Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count

Rated 4.6 out of 5 stars
27
$160.99Chewy Price
($1.35/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Long-term Effects

4.6/5
Excellent

Is this calming pill right for my pet?

Breed Size

Medium Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin

Health Feature

Calming
3
+PlusPET Pet Daily Balance Softgel Full Spectrum Hemp Extract Health Supplement for Large Breed Dogs, 30 count
+PlusPET Pet Daily Balance Softgel Full Spectrum Hemp Extract Health Supplement for Large Breed Dogs, 30 count
+PlusPET Pet Daily Balance Softgel Full Spectrum Hemp Extract Health Supplement for Large Breed Dogs, 30 count
+PlusPET Pet Daily Balance Softgel Full Spectrum Hemp Extract Health Supplement for Large Breed Dogs, 30 count

+PlusPET Pet Daily Balance Softgel Full Spectrum Hemp Extract Health Supplement for Large Breed Dogs, 30 count

Rated 4.5 out of 5 stars
13
$34.99Chewy Price
($1.17/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.7/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.3/5
Great

Long-term Effects

4.3/5
Great

Is this calming pill right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Inactive Ingredients: Extra Virgin Olive Oil, Vegan Softgel (Modified Cornstarch, Glycerin, Irish Moss, Sorbitol and Purified Water)

Special Diet

Non-GMO, Gluten Free, Vegan
4
Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count
Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count
Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count
Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count

Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count

Rated 4.4 out of 5 stars
19
$268.49Chewy Price
($2.24/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Long-term Effects

4.5/5
Great

Is this calming pill right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium Stearate, Maltodextrin

Health Feature

Calming
5
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets
maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets

maxxipaws maxxicalm Calming Aid for Dogs, 120 tablets

Rated 4 out of 5 stars
22
$34.99Chewy Price
($0.30/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.4/5
Great

Long-term Effects

4.7/5
Excellent

Is this calming pill right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Taurine, Inositol, Chamomile, Passion Flower, L-Theanine

Special Diet

Natural
6
Natura Petz Organics Serenity Zen Dog Supplement, 90 count
Natura Petz Organics Serenity Zen Dog Supplement, 90 count
Natura Petz Organics Serenity Zen Dog Supplement, 90 count

Natura Petz Organics Serenity Zen Dog Supplement, 90 count

Rated 4.5 out of 5 stars
2
$29.99Chewy Price
($0.34/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Long-term Effects

4.5/5
Great

Is this calming pill right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Gelatin Capsules, Valerian Root, Pasiflora, Chamomile, Mulungu

Special Diet

Organic, No Corn No Wheat No Soy, Non-GMO
7
Natura Petz Organics Anxiety Starter Pack Dog Supplement, 30 count
Natura Petz Organics Anxiety Starter Pack Dog Supplement, 30 count

Natura Petz Organics Anxiety Starter Pack Dog Supplement, 30 count

Rated 4 out of 5 stars
3
$19.99Chewy Price
($0.67/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Long-term Effects

4.5/5
Great

Is this calming pill right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Proprietary Herbal Blend Including Plants Such As Valerian Root, Mulungu, And Chamomile

Special Diet

Organic, No Corn No Wheat No Soy, Non-GMO