10 Best Liquid Calming Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Liquid Calming Supplements for Dogs

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How we created this liquid calming supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best liquid calming supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best liquid calming supplements for dogs.

Key liquid calming supplement considerations

Active Ingredients

Dosage and Administration

Effectiveness

Safety

1
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4.1 out of 5 stars
1,516
$18.74Chewy Price
($0.94/mL)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.2/5
Great

Dosage and Administration

4.1/5
Great

Effectiveness

4.2/5
Great

Safety

4.3/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

HPUS 5x Dilution of Helianthemum Nummularium, Clematis Vitalba, Impatiens Glandulifera, Prunus Cerasifera, Ornithogalum Umbellatum

Special Diet

Natural
2
PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle
PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle
PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle
PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle
PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle

PetAlive EaseSure-S Brain & Nervous System Support Dog & Cat Supplement, 2-fl oz bottle

Rated 4.5 out of 5 stars
123
$34.89Chewy Price
($17.45/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.4/5
Great

Dosage and Administration

4.5/5
Great

Effectiveness

4.4/5
Great

Safety

4.3/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Proprietary Formula, Passion Flower (Herb), Skullcap (Herb), Ashwagandha (Root), Fresh Wild Oat (Seed)

Special Diet

Plant Based, Vegetarian
3
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle
Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle

Wonder Paws Melatonin & L-Theanine Bacon Flavored Liquid Calming Supplement for Dogs, 2-fl oz bottle

Rated 4.3 out of 5 stars
82
$14.95Chewy Price
($7.48/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.5/5
Great

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Inactive Ingredients: Purified Water, Vegetable Glycerin, Natural Bacon Flavor, Potassium Sorbate

Food Flavor

Bacon
4
Licks Pill-Free Littles ZEN Calming Roasted Chicken Flavor Dog Supplement, 30 count
Licks Pill-Free Littles ZEN Calming Roasted Chicken Flavor Dog Supplement, 30 count

Licks Pill-Free Littles ZEN Calming Roasted Chicken Flavor Dog Supplement, 30 count

Rated 4.6 out of 5 stars
31
$29.98Chewy Price
($1.00/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.7/5
Excellent

Dosage and Administration

4.7/5
Excellent

Effectiveness

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this liquid calming supplement right for my pet?

Breed Size

Small Breeds, Extra Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Chamomile, Tryptophan, L-Theanine, Organic Eleuthero Root, Organic Ashwagandha Root. Inactive Ingredients: All Natural Savory Flavor

Special Diet

Human-Grade, Limited Ingredient Diet, Non-GMO
5
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle
NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

NaturVet Hemp Quiet Moments Liquid Calming Supplement for Cats & Dogs, 4-fl oz bottle

Rated 4 out of 5 stars
139
$25.97Chewy Price
($6.50/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.1/5
Great

Dosage and Administration

4.1/5
Great

Effectiveness

4.1/5
Great

Safety

4.2/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Thiamine, L-Tryptophan, Hemp Seed Oil, Chamomile Extract, Valerian Extract

Food Flavor

Unflavored
6
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle
Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle

Charlotte's Web Full Spectrum Hemp Extract Chicken Flavored Liquid Calming Supplement for Dogs, 30-ml bottle

Rated 4.4 out of 5 stars
24
$59.99Chewy Price
($2.00/mL)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.4/5
Great

Dosage and Administration

4.4/5
Great

Effectiveness

4.4/5
Great

Safety

4.6/5
Excellent

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

Adult, All Lifestages

Top Ingredients

Inactive Ingredients: MCT Oil, Natural Chicken Flavor

Special Diet

Non-GMO
7
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle
Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle

Wonder Paws Hemp Oil with Wild Salmon Oil, Calming Hemp Supplement for Dogs, 2-fl oz bottle

Rated 4.3 out of 5 stars
108
$21.95Chewy Price
($10.98/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.6/5
Excellent

Dosage and Administration

4.5/5
Great

Effectiveness

4.5/5
Great

Safety

4.5/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

Adult, All Lifestages

Top Ingredients

Active Ingredients: Omega-3 Fatty Acids (From Salmon Oil), Hemp Seed Oil

Food Flavor

Salmon
8
Pet Releaf Stress Releaf Organic Full Spectrum Hemp Extract Oil & Ashwagandha Liquid Calming Health Supplement for Small Dogs & Cats, 1-fl oz bottle
Pet Releaf Stress Releaf Organic Full Spectrum Hemp Extract Oil & Ashwagandha Liquid Calming Health Supplement for Small Dogs & Cats, 1-fl oz bottle

Pet Releaf Stress Releaf Organic Full Spectrum Hemp Extract Oil & Ashwagandha Liquid Calming Health Supplement for Small Dogs & Cats, 1-fl oz bottle

Rated 4.4 out of 5 stars
12
$45.99Chewy Price
($45.99/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.5/5
Great

Dosage and Administration

4.5/5
Great

Effectiveness

4.4/5
Great

Safety

4.4/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Inactive Ingredients: Organic MCT Oil

Health Feature

Calming
9
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle
Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle

Pet Wellbeing Pet Melatonin Bacon Flavored Liquid Calming Supplement for Dogs, 2-oz bottle

Rated 4.1 out of 5 stars
112
$36.95Chewy Price
($18.48/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.0/5
Great

Dosage and Administration

4.2/5
Great

Effectiveness

3.7/5
Good

Safety

4.0/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Melatonin (Synthetic; Not Animal-Derived)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor, Vegetable Glycerin

Food Flavor

Bacon, Meat
10
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle
+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle

+PlusPET Daily Balance Beef Flavored Full Spectrum Hemp Extract Oil Health Supplement for Dogs & Cats, 1.86-fl oz bottle

Rated 4.2 out of 5 stars
20
$45.99Chewy Price
($24.73/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Active Ingredients

4.5/5
Great

Dosage and Administration

4.4/5
Great

Effectiveness

4.4/5
Great

Safety

4.4/5
Great

Is this liquid calming supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Inactive Ingredients: Natural Flavor, Organic Extra Virgin Olive Oil, Quillaja Saponaria

Special Diet

Non-GMO, Gluten Free, Vegan