Onguard Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, slide 1 of 1

Onguard Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

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Onguard Plus Flea & Tick Treatment for Cats & Kittens is a long-lasting topical treatment that kills fleas and ticks and controls infestations of chewing lice. It works quickly to not only rid your cat of these pests, but keeps working to prevent them from coming back. This spot treatment is safe for kittens and cats that are at least 8 weeks old and 1.5 to 22 pounds. Onguard Plus keeps new flea eggs from hatching and rids your pet of adult fleas that can cause flea allergy dermatitis for up to 6 weeks. This powerful formula keeps killing Brown dog ticks, American dog ticks, Lone Star ticks and Deer ticks that may carry Lyme disease for up to a month. Application is easy—just squeeze this spot treatment onto your cat’s skin between the shoulder blades with the easy-to-use, redesigned applicator. Onguard Plus is long-lasting and waterproof, so it still offers protection even after a bath or if your cat’s fur gets wet. Onguard Plus is manufactured in the USA to bring you the top-quality product and top-notch flea and tick control that you expect for your pets.

Key Benefits
  • Topical treatment kills all life stages of fleas and ticks on cats at least 8 weeks old and 1.5 to 22 pounds. Also controls infestations of chewing lice.
  • Uses fipronil and (S)-methoprene, formulated to control fleas and ticks. Effective for 30 days and safe for cats 8 weeks and older.
  • Breaks the flea life cycle and rids your cat of flea eggs, larvae, pupae and adults. Also kills tick larvae, nymphs and adults.
  • Effective against fleas that cause flea allergy dermatitis as well as Brown dog ticks, American dog ticks, Lone Star ticks and Deer ticks that may carry Lyme disease.
  • Redesigned applicator makes it easier to apply this long-lasting and waterproof treatment that provides protection even after your cat has a bath or gets their fur wet.
What's Included

(6) applicators each containing 0.017 fl oz (0.50 ml)


Do not use on dogs. Keep out of reach of children. Use only on cats weighing over 1.5 lbs. and 8 weeks or older. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your cat, read the entire label and package insert before each use. Follow all directions and precautionary statements carefully. Use on cats only. Do not use on dogs, rabbits or other animals. Onguard Plus is not manufactured by or distributed by Merial Limited. Frontline is a registered trademark of Merial Limited.

Important Information

Fleas rise to the top of your cat's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet.

Onguard Plus works to eliminate fleas in all life stages. If you’re still seeing fleas after application, it may be because your cat has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. Don’t worry, Onguard Plus starts working immediately on any new fleas that get on your cat, eliminating them within 24 hours from contact. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

See all items by Onguard Plus

  • Item Number
  • Dimensions
    5.75 x 1.25 x 4.38 inches
  • Weight
    1.76 ounces
  • Administration Form
  • Usage
  • Lifestage
  • Product Form
  • Health Condition
    Fleas, Ticks

Active Ingredients: Fipronil 9.8%, (S)-Methoprene 11.8%.


To apply Onguard Plus Flea & Tick for Cats: Your cat needs to be dry at the time of application and remain dry for 24 hours after application. Part the hair on the neck at the base of the skull until the skin is visible.

Place the tip of the applicator on the skin and squeeze the applicator to apply the entire contents directly on the skin of your cat. Do not apply more than one applicator per treatment for one cat regardless of the cat's weight. Do not allow your cat to ingest this product, or get the product into their eyes. Proper placement of the product on your cat will minimize the opportunity for the cat to lick and ingest the product. Carefully avoid allowing the product to run off the side of the cat. Separate treated cat from all other cats and pets until product has dried.

Fleas: Kills newly emerged fleas before they lay eggs. Kills adult fleas which may cause flea allergy dermatitis.

Ticks: Kills ticks that may transmit Lyme disease. Kills tick nymphs and adults.

Lice: Rapidly controls infestations of chewing lice.

Frequency of Application Fleas: When used monthly, Onguard Plus Flea & Tick for Cats kills all stages of the flea life cycle and prevents reinfestation of fleas on your cat for up to six weeks after application. Although Onguard Plus Flea & Tick for Cats can control fleas for up to six weeks, if there is a high risk of re-infestation of fleas on your cat, or if the cat has fleas which may cause flea allergy dermatitis, apply Onguard Plus Flea & Tick for Cats once every 30 days.

Ticks: Onguard Plus Flea & Tick for Cats kills all stages of the tick life cycle (larvae, nymph, and adult) for at least 30 days. For best control of ticks, apply once every 30 days.

Chewing Lice: Onguard Plus Flea & Tick for Cats kills chewing lice for at least 30 days. For best control of chewing lice, apply once every 30 days.

Do not reapply Onguard Plus Flea & Tick for Cats for 30 days.


Is Onguard Plus Flea & Tick A topical application?

Yes, Onguard Plus for cats is a topical flea & tick. This means that the Flea & Tick solution is applied directly to your pet’s skin.

What is the difference between Onguard Flea & Tick and oral flea and tick products?

Onguard Plus Flea & Tick is applied directly to the pet’s skin rather than administered orally. Topical solutions kill fleas through contact with the product on the pet’s skin. Unlike most oral flea products, fleas do not need to bite your pet to be killed.

What are the active ingredients?

Active ingredients are Fipronil 9.80% and (S)-methoprene 11.80%.

How old does my cat need to be/or weigh to use Onguard Plus Flea & Tick for Cats?

Onguard Plus Flea & Tick is for cats 8 weeks and older weighing more than 1.5 pounds.

Can this flea & tick topical be applied to pregnant or nursing cats?

This product is approved for use for breeding, pregnant and lactating cats.

What is the best way to apply?

To apply, place between the shoulder blades on the cat’s back. The topical will be dispersed over your cat’s body through their natural oils and attached to the hair follicles. This process can take up to 24 hours. Do not apply more often than once every 4 weeks.

Can Onguard Plus be applied immediately after bathing?

For best results, apply topical 24-48 hours after bathing.

Should flea & tick topicals be used on indoor cats?

Yes, fleas can be brought inside from you or other pets.

Can I use a flea and tick collar or oral treatment while using this flea & tick topical?

Due to risk of overdose, do not use additional flea products.

How long should I wait between application of my pet’s old flea and tick treatment to this flea & tick topical?

We recommend consulting your veterinarian to advise best transition of flea & tick topical.

Will I stop seeing fleas after the first application?

This topical begins to kill flea within the first 24-48 hours after application. It may take up to 72 hours to reach full efficacy.

What if I still see fleas on my cat after treatment?

If fleas are present immediately after application, it may take up to 72 hours to reach full efficacy.

How often should you apply Onguard Plus Flea & Tick for Cats?

Each application helps to stop biting fleas, flea eggs and larvae, and ticks for up to one month. Do not apply more often than once every 4 weeks.

Is Onguard Plus waterproof?

Onguard Plus is waterproof. For best results, use a gentle grooming shampoo. Do not reapply Onguard Plus after bathing. Can I apply Onguard Flea & Tick Plus for Cats on my dog or Onguard Flea & Tick Plus for Dogs on my cat?

No, never apply a cat product on a dog, or a dog product on a cat; it is always recommended to apply the proper product for your pet.

About Onguard Plus Flea & Tick for Cats

Onguard Plus for cats

One Solution, Powerful Protection

Onguard Plus is a monthly topical spot treatment that helps eliminate fleas and ticks and protects your pet from painful bites and infestations. This flea and tick preventative treatment not only stops ticks and fleas in their tracks, but also prevents the hatching of new fleas and keeps fighting off ticks so your cat can find relief from these pests.

Preventing Fleas at Every Turn

Fleas are not only a nuisance for your kitty, but they may also cause bigger problems like flea allergy dermatitis. The best way to prevent and eliminate a flea problem is to attack them at all life stages, which Onguard Plus does efficiently.

Flea finds a home

Once on your cat, it bites to feed within just 2 hours.

Eggs are laid

In 2 days, an adult flea will lay eggs.

Eggs hatch into larvae

Eggs fall off your pet, scatter around the home, and then hatch.

Larvae turn into pupae

Pupae can wait for up to a year before emerging as adult fleas.

2 Powerful Active Ingredients

Onguard Plus uses two active ingredients that are commonly used to protect cats from fleas and ticks. Fipronil and (S)-methoprene work together to stop an infestation in its tracks and prevent future ones. Fipronil kills adult fleas, ticks and chewing lice and aids eliminating flea eggs and larvae by disrupting their maturation. Together the two create a highly effective flea and tick preventative treatment. 

One-Step Application

These topical flea and tick treatments are easy to apply and effective for up to 30 days. Choose from three treatments or six so you can keep your pet protected. Simply apply it between the shoulder blades of your pet, and the long-lasting solution will keep protecting them from fleas and ticks. The formula is both waterproof and sunlight-proof, so you don’t have to worry about reapplication throughout the month. 

Combats Ticks for a Healthy Pet

Combats Ticks for a Healthy Pet

Onguard Plus is an effective preventative that kills ticks at all life stages and keeps them from coming back. Monthly applications of Onguard Plus can protect your pet from ticks that may carry Lyme disease and Rocky Mountain spotted fever. It kills many of the most common types of ticks that carry these diseases.

About Onguard Plus Flea & Tick

Onguard Plus is dedicated to protecting cats and dogs from the discomfort of disease that come along with flea and tick infestations. That is why they offer efficient and effective flea and tick treatments that will keep your pet happy and healthy. Their monthly solutions for flea and tick prevention are convenient and ideal for busy pet parents who want to spend more time with their pets, not fighting off fleas and ticks.

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About Onguard Plus Flea & Tick

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