10 Best Flea & Tick Treatments for Cats 2025: According to Reviews | Chewy

The 10 Best Cat Flea & Tick Remedies

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How we created this flea & tick treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best flea & tick treatments for cat.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best flea & tick treatments for cats.

Key flea & tick treatment considerations

Duration of Protection

Ease of Application

Effectiveness

Safety

1
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)

Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
8,367
$68.98Chewy Price
($11.50/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.2/5
Great

Ease of Application

4.4/5
Great

Effectiveness

4.2/5
Great

Safety

4.2/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%
2
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)
Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)

Cheristin Flea Spot Treatment for Cats, over 1.8 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
2,788
$78.69Chewy Price
($13.12/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Application

4.4/5
Great

Effectiveness

4.5/5
Great

Safety

4.2/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%
3
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)

Seresto Flea & Tick Collar for Cats, 1 Collar (8-mos. supply)

Rated 4.3 out of 5 stars
7,565
$59.58Chewy Price
($59.58/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.2/5
Great

Ease of Application

4.2/5
Great

Effectiveness

4.2/5
Great

Safety

4.2/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Flumethrin 4.5%, Imidacloprid 10.0%

Collar Type

Flea & Tick
4
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets

Capstar Flea Oral Treatment for Cats, 2-25 lbs, 6 Tablets

Rated 4.4 out of 5 stars
3,242
$39.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Application

4.4/5
Great

Effectiveness

4.3/5
Great

Safety

4.2/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Active ingredients: Nitenpyram 11.4mg

Health Feature

Anti-Parasitic, Pest Control
5
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs

Frisco Single-Row Flea Comb for Cats & Dogs

Rated 4.7 out of 5 stars
671
$2.50Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.5/5
Great

Ease of Application

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Safety

4.6/5
Excellent

Is this flea & tick treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Stages
6
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments
Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments

Advantage Topical Flea Prevention for Large Cats, 9 lbs+, 2-Monthly Treatments

Rated 4.5 out of 5 stars
450
$14.98Chewy Price
($7.49/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.4/5
Great

Ease of Application

4.3/5
Great

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredient

Imidacloprid

Health Feature

Anti-Parasitic, Pest Control
7
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count
Advantage XD Large Cat Treatment, 2 count

Advantage XD Large Cat Treatment, 2 count

Rated 4.4 out of 5 stars
450
$55.98Chewy Price
($27.99/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Application

4.4/5
Great

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Spinetoram 15%, Other Ingredients 85.0%

Food Form

Supplement
8
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)

Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 6 Doses (6-mos. supply)

Rated 4.1 out of 5 stars
6,561
$68.98Chewy Price
($11.50/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

3.9/5
Good

Ease of Application

4.0/5
Great

Effectiveness

3.8/5
Good

Safety

3.9/5
Good

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%
9
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Rated 4.5 out of 5 stars
427
$32.29Chewy Price
($2.02/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.5/5
Great

Ease of Application

4.5/5
Great

Effectiveness

4.4/5
Great

Safety

4.2/5
Great

Is this flea & tick treatment right for my pet?

Breed Size

Small Breeds, Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Pyriproxyfen .10%, Pyrethrins, a botanical insecticide .05%, n-Octyl bicycloheptene dicarboximide* .40%, Permethrin .40%
10
Master Grooming Tools Contoured Grip Flea Dog & Cat Comb
Master Grooming Tools Contoured Grip Flea Dog & Cat Comb

Master Grooming Tools Contoured Grip Flea Dog & Cat Comb

Rated 4.7 out of 5 stars
221
$5.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Application

4.8/5
Excellent

Effectiveness

4.6/5
Excellent

Safety

4.7/5
Excellent

Is this flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Small Pet Type

Rabbit, Guinea Pig, Chinchilla, Gerbil...