10 Best Dog Flea & Tick Treatments 2026: According to Reviews | Chewy

The 10 Best Dog Flea & Tick Treatments

How we created this dog flea & tick treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best dog flea & tick treatment.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best dog flea & tick treatments.

Key dog flea & tick treatment considerations

Duration of Protection

Ease of Use

Effectiveness

Safety

Our Top Picks

1
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)

Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)

Rated 4.4 out of 5 stars
25,176
$50.99 Chewy Price
($50.99/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.4/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Safety

4.4/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Flumethrin 4.5%, Imidacloprid 10.0%

Collar Type

Flea & Tick
2
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Rated 4.4 out of 5 stars
7,103
$74.98 Chewy Price
($12.50/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.3/5
Great

Effectiveness

4.2/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%

Health Feature

Pest Control
3
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
6,259
$63.99 Chewy Price
($10.67/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.3/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%

Health Feature

Pest Control
4
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs
Frisco Single-Row Flea Comb for Cats & Dogs

Frisco Single-Row Flea Comb for Cats & Dogs

Rated 4.7 out of 5 stars
1,043
$3.06 Chewy Price
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.5/5
Great

Ease of Use

4.6/5
Excellent

Effectiveness

4.5/5
Great

Safety

4.5/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

All Breeds

Lifestage

Adult, All Lifestages

Health Feature

Dental & Breath Care, Skin & Coat Health
5
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

PetArmor Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Rated 4.4 out of 5 stars
1,243
$31.99 Chewy Price
($5.34/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Fipronil 9.80%, (S)-methoprene 8.80%

Health Feature

Pest Control, Anti-Parasitic
6
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)

Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
838
$89.99 Chewy Price
($15.00/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.4/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.4/5
Great

Safety

4.3/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Dinitefuran, Pyriproxyfen, Permethrin

Special Diet

Indoor
7
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
1,121
$66.99 Chewy Price
($11.17/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.3/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%

Health Feature

Pest Control
8
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Rated 4.1 out of 5 stars
1,104
$18.85 Chewy Price
($3.15/ea)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.2/5
Great

Effectiveness

4.2/5
Great

Safety

4.1/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%

Health Feature

Skin & Coat Health
9
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Rated 4.5 out of 5 stars
550
$33.29 Chewy Price
($2.09/fl oz)
Promo, Save 30% today with Autoship

Our ratings

Duration of Protection

4.4/5
Great

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Safety

4.1/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Pyriproxyfen .10%, Pyrethrins, a botanical insecticide .05%, n-Octyl bicycloheptene dicarboximide* .40%, Permethrin .40%

Health Feature

Pest Control
10
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle
Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle

Absorbine UltraShield EX Insecticide, Kills & Repels Horse Fly Spray Refill, 128-fl oz bottle

Rated 4.7 out of 5 stars
349
$79.19 Chewy Price
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Duration of Protection

4.6/5
Excellent

Ease of Use

4.5/5
Great

Effectiveness

4.6/5
Excellent

Safety

4.4/5
Great

Is this dog flea & tick treatment right for my pet?

Top Ingredients

Permethrin, Pyrethrins, Piperonyl Butoxide

Farm Animal Type

Horse

Health Feature

Pest Control