10 Best Dog Flea & Tick Treatments 2025: According to Reviews | Chewy

The 10 Best Dog Flea & Tick Treatments

Jump to the list

How we created this dog flea & tick treatment list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best dog flea & tick treatment.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best dog flea & tick treatments.

Key dog flea & tick treatment considerations

Duration of Protection

Ease of Use

Effectiveness

Safety

1
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)
Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)

Seresto Flea & Tick Collar for Dogs, over 18-lbs, 1 Collar (8-mos. supply)

Rated 4.4 out of 5 stars
21,683
$59.98Chewy Price
($59.98/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.4/5
Great

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Safety

4.3/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Flumethrin 4.5%, Imidacloprid 10.0%

Collar Type

Flea & Tick
2
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

K9 Advantix II Flea & Tick Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
5,581
$79.98Chewy Price
($13.33/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.3/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%
3
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Rated 4.4 out of 5 stars
6,128
$59.99Chewy Price
($10.00/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.1/5
Great

Ease of Use

4.3/5
Great

Effectiveness

4.1/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%
4
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)
PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)

PetArmor Plus Flea & Tick Spot Treatment for Dogs, 5-22 lbs, 6 Doses (6-mos. supply)

Rated 4.4 out of 5 stars
1,330
$39.93Chewy Price
($6.66/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.2/5
Great

Effectiveness

4.1/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Extra Small Breeds, Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Fipronil 9.80%, (S)-methoprene 8.80%

Health Feature

Anti-Parasitic, Pest Control
5
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)
Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Advantage II Flea Spot Treatment for Dogs, over 55 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
1,003
$66.98Chewy Price
($11.17/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.3/5
Great

Effectiveness

4.3/5
Great

Safety

4.2/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%
6
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)
Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)

Vectra 3D Flea & Tick Spot Treatment for Dogs, 56-95 lbs, 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
709
$89.99Chewy Price
($15.00/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.5/5
Great

Ease of Use

4.4/5
Great

Effectiveness

4.5/5
Great

Safety

4.3/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Dinitefuran, Pyriproxyfen, Permethrin

Special Diet

Indoor
7
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)
Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Onguard Plus Flea & Tick Spot Treatment for Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

Rated 4.1 out of 5 stars
995
$22.33Chewy Price
($3.73/ea)
Promo, Buy 3, get 4th free- mix & match

Our ratings

Duration of Protection

4.2/5
Great

Ease of Use

4.2/5
Great

Effectiveness

4.2/5
Great

Safety

4.1/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%
8
Master Grooming Tools Contoured Grip Flea Dog & Cat Comb
Master Grooming Tools Contoured Grip Flea Dog & Cat Comb

Master Grooming Tools Contoured Grip Flea Dog & Cat Comb

Rated 4.7 out of 5 stars
275
$5.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.3/5
Great

Ease of Use

4.7/5
Excellent

Effectiveness

4.6/5
Excellent

Safety

4.6/5
Excellent

Is this dog flea & tick treatment right for my pet?

Lifestage

All Lifestages, Adult

Small Pet Type

Rabbit, Guinea Pig, Chinchilla, Gerbil...
9
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can
Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Virbac Knockout E.S. Area Treatment Spray, 16-fl oz can

Rated 4.5 out of 5 stars
501
$32.29Chewy Price
($2.02/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.4/5
Great

Ease of Use

4.5/5
Great

Effectiveness

4.5/5
Great

Safety

4.0/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Pyriproxyfen .10%, Pyrethrins, a botanical insecticide .05%, n-Octyl bicycloheptene dicarboximide* .40%, Permethrin .40%
10
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets
Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets

Capstar Flea Oral Treatment for Dogs, over 25 lbs, 6 Tablets

Rated 4.1 out of 5 stars
1,922
$43.19Chewy Price
($7.20/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Duration of Protection

4.0/5
Great

Ease of Use

4.1/5
Great

Effectiveness

4.0/5
Great

Safety

4.0/5
Great

Is this dog flea & tick treatment right for my pet?

Breed Size

Medium Breeds, Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Active Ingredient: Nitenpyram

Health Feature

Pest Control, Anti-Parasitic