Prescription Flea & Tick Medicine for Dogs

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NexGard Chew for Dogs, 24.1-60 lbs, (Purple Box), 3 Chews (3-mos. supply)

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Rated 4.6544 out of 5 stars
790
$68.99Chewy Price
$65.54Autoship Price

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Heartgard Plus Chew for Dogs, 51-100 lbs, (Brown Box), 6 Chews (6-mos. supply) & NexGard Chew for Dogs, 4-10 lbs, (Orange Box), 6 Chews (6-mos. supply)
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Rated 5 out of 5 stars
1
$189.92Chewy Price
$189.98List Price
$180.42Autoship Price

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Bravecto Chew for Dogs, 44-88 lbs, (Blue Box), 1 Chew (12-wks. supply)

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Rated 4.544 out of 5 stars
636
$63.99Chewy Price

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NexGard Chew for Dogs, 60.1-121 lbs, (Red Box), 3 Chews (3-mos. supply)

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Rated 4.7125 out of 5 stars
793
$68.99Chewy Price
$65.54Autoship Price

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Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.5672 out of 5 stars
238
$168.41Chewy Price
$159.99Autoship Price

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NexGard Chew for Dogs, 10.1-24 lbs, (Blue Box), 3 Chews (3-mos. supply)

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Rated 4.7528 out of 5 stars
720
$68.99Chewy Price
$65.54Autoship Price

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Simparica Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.5987 out of 5 stars
299
$110.98Chewy Price
$105.43Autoship Price

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Bravecto Chew for Dogs, 9.9-22 lbs, (Orange Box), 1 Chew (12-wks. supply)

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Rated 4.726 out of 5 stars
354
$61.99Chewy Price

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Interceptor Plus Chew for Dogs, 50.1-100 lbs, (Blue Box), 6 Chews (6-mos. supply) & Credelio Chewable Tablet for Dogs, 25.1-50 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)

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$171.52Chewy Price
$162.94Autoship Price

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Credelio Chewable Tablet for Dogs, 50.1-100 lbs, (Blue Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.6269 out of 5 stars
67
$113.80Chewy Price
$108.11Autoship Price

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Bravecto Chew for Dogs, 22-44 lbs, (Green Box), 1 Chew (12-wks. supply)

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Rated 4.5424 out of 5 stars
271
$63.49Chewy Price

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Revolution Topical Solution for Dogs, 20.1-40 lbs, (Red Box), 6 Doses (6-mos. supply)

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Rated 4.7222 out of 5 stars
72
$137.99Chewy Price
$131.09Autoship Price

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Heartgard Plus Chew for Dogs, 26-50 lbs, (Green Box), 1 Chew (1-mo. supply) & NexGard Chew for Dogs, 60.1-121 lbs, (Red Box), 1 Chew (1-mo. supply)

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$33.99Chewy Price
$35.98List Price
$32.29Autoship Price

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NexGard Chew for Dogs, 4-10 lbs, (Orange Box), 3 Chews (3-mos. supply)

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Rated 4.6728 out of 5 stars
217
$68.99Chewy Price
$65.54Autoship Price

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Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.6311 out of 5 stars
122
$150.97Chewy Price
$143.42Autoship Price

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Trifexis Chewable Tablet for Dogs, 60.1-120 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.5794 out of 5 stars
233
$124.99Chewy Price
$127.49List Price
$118.74Autoship Price

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Simparica Trio Chewable Tablet for Dogs, 22.1-44.0 lbs, (Teal Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.6168 out of 5 stars
107
$163.53Chewy Price
$155.35Autoship Price

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Simparica Chewable Tablet for Dogs, 11.1-22 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.6909 out of 5 stars
165
$99.67Chewy Price
$94.69Autoship Price

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Bravecto Chew for Dogs, 88-123 lbs, (Pink Box), 1 Chew (12-wks. supply)

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Rated 4.6111 out of 5 stars
162
$64.99Chewy Price

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Sentinel Tablet for Dogs, 11-25 lbs, (Green Box), 6 Tablets (6-mos. supply)

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Rated 4.4302 out of 5 stars
172
$50.49Chewy Price

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Credelio Chewable Tablet for Dogs, 25.1-50 lbs, (Green Box), 1 Chewable Tablet (1-mo. supply)

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Rated 4.1509 out of 5 stars
53
$22.65Chewy Price
$21.52Autoship Price

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Bravecto Chew for Dogs, 4.4-9.9 lbs, (Yellow Box), 1 Chew (12-wks. supply)

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Rated 4.7048 out of 5 stars
105
$59.99Chewy Price

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Advantage Multi Topical Solution for Dogs, 20.1-55 lbs, (Red Box), 6 Doses (6-mos. supply)

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Rated 4.5965 out of 5 stars
57
$115.99Chewy Price
$127.74List Price
$110.19Autoship Price

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Simparica Chewable Tablet for Dogs, 22.1-44 lbs, (Mint Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.7177 out of 5 stars
124
$107.88Chewy Price
$102.49Autoship Price

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Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.7059 out of 5 stars
68
$170.73Chewy Price
$162.19Autoship Price

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Bravecto Topical Solution for Dogs, 9.9-22 lbs, (Orange Box), 1 Dose (12-wks. supply)

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Rated 4.069 out of 5 stars
29
$53.99Chewy Price

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Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.6055 out of 5 stars
289
$117.39Chewy Price
$111.52Autoship Price

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Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.7013 out of 5 stars
77
$148.34Chewy Price
$140.92Autoship Price

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Credelio Chewable Tablet for Dogs, 12.1-25 lbs, (Orange Box), 1 Chewable Tablet (1-mo. supply)

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Rated 4.2656 out of 5 stars
64
$20.59Chewy Price
$19.56Autoship Price

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Sentinel Tablet for Dogs, 51-100 lbs, (White Box), 6 Tablets (6-mos. supply)

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Rated 4.6915 out of 5 stars
188
$72.49Chewy Price

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Revolution Topical Solution for Dogs, 86-130 lbs, (Plum Box), 3 Doses (3-mos. supply)

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Rated 4.7273 out of 5 stars
33
$96.49Chewy Price
$91.67Autoship Price

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Trifexis Chewable Tablet for Dogs, 40.1-60 lbs, (Blue Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.544 out of 5 stars
182
$122.99Chewy Price
$125.49List Price
$116.84Autoship Price

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Bravecto 1-Month Chew for Dogs, 9.9-22 lbs, (Orange Box), 1 Chew (1-mo. supply)
Rated 4.25 out of 5 stars
4
$20.49Chewy Price

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Advantage Multi Topical Solution for Dogs, 9.1-20 lbs, (Teal Box), 6 Doses (6-mos. supply)

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Rated 4.7302 out of 5 stars
63
$113.15Chewy Price
$127.74List Price
$107.49Autoship Price

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Simparica Chewable Tablet for Dogs, 88.1-132 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.4314 out of 5 stars
51
$112.53Chewy Price
$106.90Autoship Price

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Trifexis Chewable Tablet for Dogs, 20.1-40 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)

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Rated 4.5936 out of 5 stars
187
$120.49Chewy Price
$122.99List Price
$114.47Autoship Price

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Prescription Flea & Tick Medicine for Dogs

Keep biting pests from plaguing your pup with a prescription flea and tick medicine for dogs. Chewy carries several types of prescription flea and tick treatment, including prescription topical flea & tick treatment for dogs, prescription flea & tick pills for dogs and prescription flea and tick medicines that also prevent heartworms and other parasites.

Before you choose a prescription flea and tick medication, be sure to research your different options. The best flea and tick medicine will be easy to administer, suited to your dog's lifestyle, and effective for the climate you live in. Most prescription flea medication for dogs also provides tick protection, but check the product label just to be sure.

Prescription flea and tick topical treatments are easy to apply and can provide continuous protection that lasts for a month or more. Many are also water-resistant, so they won't interfere with regular bathing and grooming. Several prescription oral flea and tick treatments can provide long-lasting pest deterrence that's water-friendly, too. Many of these prescription flea pills and chewables offer heartworm protection, as well.

Your vet can advise you on what kind of prescription flea and tick medicine to choose and provide you with the prescription you need to buy it. Chewy has all the best flea and tick preventatives, including the ones your veterinarian recommends most. Shop our Pet Pharmacy for prescription flea and tick medicine for dogs and get everything your best friend needs for an itch-free life!

Frequently Asked Questions about Prescription Flea & Tick Medicine for Dogs

How do I get dog flea and tick medication prescriptions online at Chewy Pharmacy?

Get dog flea and tick medication prescriptions online at Chewy Pharmacy by visiting your vet and talking about flea and tick control options. Your vet can then write you a prescription for the product and dose what’s appropriate for your pup. Then, go online and add the prescribed product to your cart. At checkout, you can add your dog’s info and vet contact information so Chewy can verify the prescription on your behalf. That’s all you need to do to order your prescription medications from Chewy!

What prescription dog flea and tick treatment is best?

The best prescription flea and tick treatment will vary by the age, health, lifestyle and habits of your dog and can best be determined by your vet. Popular brands include Comfortis, Advantage Multi, Simparica Trio, Revolution and Credelio, but there are many others that may uniquely suit your situation. Many come as once-a-month topicals or chewable tablet doses for easy use. Check out some of the great reviews on our site to learn more about which ones might be best for your bestie!

What is the difference between over-the-counter and prescription dog flea and tick medication?

The difference between over-the-counter and prescription flea and tick medication is that you need a vet to prescribe the latter. The ingredients in prescription medications are more carefully controlled and regulated, and therefore, dosing may be more precise and possibly safer. Many prescription treatments are more effective than over the counter products, as well. Your vet can give you the most up-to-date information on what works well, what’s safest and what’s right for your pup.

How do dog flea treatments work?

Dog flea treatments work in different ways depending on which product you use. Prescription oral and topical flea treatments usually work by depositing chemicals into the sebaceous glands of your dog. These chemicals then spread out over the body as your dog’s coat lubricates itself, neutralizing fleas and ticks by acting on their central nervous system. This prevents them from feeding on your pup and causing irritation, itch, parasites and disease.

How do I set up Autoship for my prescription dog medicine?

To set up Autoship for your prescription dog medicine, select the Autoship option at checkout and choose how often you want it delivered. Once you set up Autoship, you can cancel or change your deliveries any time you want. You must have a valid prescription or remaining refills on file for Autoship pharmacy deliveries to occur. If we do not have a prescription, or if your prescription is expiring soon, one of our team members will reach out to your vet to obtain all the necessary information. You’ll always have your prescription dog medicines on hand when you choose Autoship from Chewy!