Prescription Flea & Tick Medicine for Dogs

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NexGard Chew for Dogs, 24.1-60 lbs, (Purple Box), 3 Chews (3-mos. supply)

Rated 4.4796 out of 5 stars
957
$75.99Chewy Price
$81.49List Price

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Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. s...

Rated 4.2355 out of 5 stars
467
$180.99Chewy Price

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NexGard Chew for Dogs, 60.1-121 lbs, (Red Box), 3 Chews (3-mos. supply)

Rated 4.5968 out of 5 stars
950
$76.99Chewy Price
$82.39List Price

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Bundle: Heartgard Plus Chew for Dogs, 51-100 lbs, (Brown Box), 6 Chews (6-mos. supply) & NexGar...

Rated 4.1111 out of 5 stars
9
$209.48Chewy Price

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Bravecto Chew for Dogs, 44-88 lbs, (Blue Box), 1 Chew (12-wks. supply)

Rated 4.344 out of 5 stars
782
$71.99Chewy Price

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NexGard Chew for Dogs, 10.1-24 lbs, (Blue Box), 3 Chews (3-mos. supply)

Rated 4.6422 out of 5 stars
858
$74.79Chewy Price
$79.79List Price

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Simparica Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply...

Rated 4.2466 out of 5 stars
373
$118.99Chewy Price

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Bravecto Chew for Dogs, 9.9-22 lbs, (Orange Box), 1 Chew (12-wks. supply)

Rated 4.6273 out of 5 stars
440
$68.99Chewy Price

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Simparica Trio Chewable Tablet for Dogs, 22.1-44.0 lbs, (Teal Box), 6 Chewable Tablets (6-mos. ...

Rated 4.3732 out of 5 stars
209
$175.99Chewy Price

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Credelio Chewable Tablet for Dogs, 50.1-100 lbs, (Blue Box), 6 Chewable Tablets (6-mos. supply)...

Rated 4.3837 out of 5 stars
86
$130.26Chewy Price

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Bundle: Interceptor Plus Chew for Dogs, 50.1-100 lbs, (Blue Box), 6 Chews (6-mos. supply) & Cre...

Rated 2.6667 out of 5 stars
3
$180.38Chewy Price
$200.43List Price

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NexGard Chew for Dogs, 4-10 lbs, (Orange Box), 3 Chews (3-mos. supply)

Rated 4.6062 out of 5 stars
259
$73.19Chewy Price
$78.09List Price

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Simparica Trio Chewable Tablet for Dogs, 11.1-22.0 lbs, (Caramel Box), 6 Chewable Tablets (6-mo...

Rated 4.3684 out of 5 stars
247
$161.99Chewy Price

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Bravecto Chew for Dogs, 22-44 lbs, (Green Box), 1 Chew (12-wks. supply)

Rated 4.4162 out of 5 stars
334
$70.99Chewy Price

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Bundle: Heartgard Plus Chew for Dogs, 26-50 lbs, (Green Box), 1 Chew (1-mo. supply) & NexGard C...

$41.28Chewy Price

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Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply...

Rated 4.5501 out of 5 stars
329
$129.14Chewy Price

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Sentinel Tablet for Dogs, 11-25 lbs, (Green Box), 6 Tablets (6-mos. supply)

Rated 4.3949 out of 5 stars
195
$50.99Chewy Price

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Simparica Chewable Tablet for Dogs, 11.1-22 lbs, (Orange Box), 6 Chewable Tablets (6-mos. suppl...

Rated 4.4 out of 5 stars
200
$106.99Chewy Price

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Bravecto Chew for Dogs, 88-123 lbs, (Pink Box), 1 Chew (12-wks. supply)

Rated 4.4619 out of 5 stars
197
$71.99Chewy Price

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Senergy Topical Solution for Puppies & Kittens, up to 5 lbs, (Mauve Box), 3 Doses (3-mos. suppl...

Rated 3 out of 5 stars
4
$41.58Chewy Price
$45.74List Price

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Credelio Chewable Tablet for Dogs, 25.1-50 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)...

Rated 3.9846 out of 5 stars
65
$126.99Chewy Price

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Advantage Multi Topical Solution for Dogs, 9.1-20 lbs, (Teal Box), 6 Doses (6-mos. supply)

Rated 4.5443 out of 5 stars
79
$128.49Chewy Price

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Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos...

Rated 4.578 out of 5 stars
109
$182.67Chewy Price

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Revolt Topical Solution for Dogs, 10.1-20 lbs, (Brown Box), 6 Doses (6-mos. supply)

Rated 4.125 out of 5 stars
8
$65.94Chewy Price

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Sentinel Spectrum Chew for Dogs, 50.1-100 lbs, (Blue Box), 6 Chews (6-mos. supply)

Rated 4.2388 out of 5 stars
134
$77.99Chewy Price

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Selarid Topical Solution for Dogs, 20.1-40 lbs, (Red Box), 6 Doses (6-mos. supply)

Rated 4.3333 out of 5 stars
6
$69.99Chewy Price

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Trifexis Chewable Tablet for Dogs, 20.1-40 lbs, (Green Box), 6 Chewable Tablets (6-mos. supply)...

Rated 4.4413 out of 5 stars
213
$132.42Chewy Price

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Sentinel Tablet for Dogs, 51-100 lbs, (White Box), 6 Tablets (6-mos. supply)

Rated 4.5822 out of 5 stars
213
$72.99Chewy Price

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Simparica Chewable Tablet for Dogs, 22.1-44 lbs, (Mint Box), 6 Chewable Tablets (6-mos. supply)...

Rated 4.6276 out of 5 stars
145
$115.99Chewy Price

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Bravecto Chew for Dogs, 4.4-9.9 lbs, (Yellow Box), 1 Chew (12-wks. supply)

Rated 4.6047 out of 5 stars
129
$67.99Chewy Price

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Senergy Topical Solution for Dogs, 5.1-10 lbs, (Lavendar Box), 3 Doses (3-mos. supply)

$46.54Chewy Price
$51.19List Price

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Credelio Chewable Tablet for Dogs, 12.1-25 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply...

Rated 4.2222 out of 5 stars
90
$123.95Chewy Price

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Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box), 6 Chewable Tablets (6-mos....

Rated 4.4141 out of 5 stars
128
$159.99Chewy Price

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Advantage Multi Topical Solution for Dogs, 3-9 lbs, (Green Box), 6 Doses (6-mos. supply)

Rated 4.3871 out of 5 stars
31
$127.88Chewy Price

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Revolution Topical Solution for Dogs, 20.1-40 lbs, (Red Box), 6 Doses (6-mos. supply)

Rated 4.5 out of 5 stars
90
$151.99Chewy Price

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Sentinel Spectrum Chew for Dogs, 25.1-50 lbs, (Yellow Box), 6 Chews (6-mos. supply)

Rated 4.4648 out of 5 stars
71
$64.99Chewy Price

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Shop Flea & Tick and Heartworm Prevention Bundles


Prescription Flea & Tick Medicine for Dogs

Keep biting pests from plaguing your pup with a prescription flea and tick medicine for dogs. Chewy carries several types of prescription flea and tick treatment, including prescription topical flea & tick treatment for dogs, prescription flea & tick pills for dogs and prescription flea and tick medicines that also prevent heartworms and other parasites.

Before you choose a prescription flea and tick medication, be sure to research your different options. The best flea and tick medicine will be easy to administer, suited to your dog's lifestyle, and effective for the climate you live in. Most prescription flea medication for dogs also provides tick protection, but check the product label just to be sure.

Prescription flea and tick topical treatments are easy to apply and can provide continuous protection that lasts for a month or more. Many are also water-resistant, so they won't interfere with regular bathing and grooming. Several prescription oral flea and tick treatments can provide long-lasting pest deterrence that's water-friendly, too. Many of these prescription flea pills and chewables offer heartworm protection, as well.

Your vet can advise you on what kind of prescription flea and tick medicine to choose and provide you with the prescription you need to buy it. Chewy has all the best flea and tick preventatives, including the ones your veterinarian recommends most. Shop our Pet Pharmacy for prescription flea and tick medicine for dogs and get everything your best friend needs for an itch-free life!

Frequently Asked Questions about Prescription Flea & Tick Medicine for Dogs

How do I get dog flea and tick medication prescriptions online at Chewy Pharmacy?

Get dog flea and tick medication prescriptions online at Chewy Pharmacy by visiting your vet and talking about flea and tick control options. Your vet can then write you a prescription for the product and dose what’s appropriate for your pup. Then, go online and add the prescribed product to your cart. At checkout, you can add your dog’s info and vet contact information so Chewy can verify the prescription on your behalf. That’s all you need to do to order your prescription medications from Chewy!

How do I set up Autoship for my prescription dog medicine?

To set up Autoship for your prescription dog medicine, select the Autoship option at checkout and choose how often you want it delivered. Once you set up Autoship, you can cancel or change your deliveries any time you want. You must have a valid prescription or remaining refills on file for Autoship pharmacy deliveries to occur. If we do not have a prescription, or if your prescription is expiring soon, one of our team members will reach out to your vet to obtain all the necessary information. You’ll always have your prescription dog medicines on hand when you choose Autoship from Chewy!

What prescription dog flea and tick treatment is best?

The best prescription flea and tick treatment will vary by the age, health, lifestyle and habits of your dog and can best be determined by your vet. Popular brands include Comfortis, Advantage Multi, Simparica Trio, Revolution and Credelio, but there are many others that may uniquely suit your situation. Many come as once-a-month topicals or chewable tablet doses for easy use. Check out some of the great reviews on our site to learn more about which ones might be best for your bestie!

What is the difference between over-the-counter and prescription dog flea and tick medication?

The difference between over-the-counter and prescription flea and tick medication is that you need a vet to prescribe the latter. The ingredients in prescription medications are more carefully controlled and regulated, and therefore, dosing may be more precise and possibly safer. Many prescription treatments are more effective than over the counter products, as well. Your vet can give you the most up-to-date information on what works well, what’s safest and what’s right for your pup.

How do dog flea treatments work?

Dog flea treatments work in different ways depending on which product you use. Prescription oral and topical flea treatments usually work by depositing chemicals into the sebaceous glands of your dog. These chemicals then spread out over the body as your dog’s coat lubricates itself, neutralizing fleas and ticks by acting on their central nervous system. This prevents them from feeding on your pup and causing irritation, itch, parasites and disease.